鼠伤寒沙门氏菌O:9,12和O:4,5,12 his+转导子对小鼠毒力的比较。
Comparison of the virulence of O:9,12 and O:4,5,12 Salmonella typhimurium his+ transductants for mice.
作者信息
Lyman M B, Stocker B A, Roantree R J
出版信息
Infect Immun. 1977 Feb;15(2):491-9. doi: 10.1128/iai.15.2.491-499.1977.
Abstract
The purpose of these experiments was to determine whether qualitative differences in the O repeat unit of the lipopolysaccharide of pathogenic Salmonella species affected virulence for mice. O:4,5,12 and O:9,12 sister his+ transductants were derived from a virulent Salmonella typhimurium. Fermentation markers were introduced by transduction to differentiate these strains, and the strains were used as mixed challenge to CF1 and C57B1/6J mice. Liver and spleen cultures of the mice of various intervals after challenge indicated that the O:4,5,12 member of the nearly isogenic pair regularly multiplied to a greater extent than the O:9,12 after intraperitoneal challenge for both strains of mice. After oral challenge, there was little difference in the amount of multiplication of the O:4,5,12 and O:9,12 strains in CF1 mice, but the O:4,5,12 was the predominant strain recovered in 8 of 10 instances in the C57B1/6J mice.
摘要
这些实验的目的是确定致病性沙门氏菌属脂多糖O重复单元的质量差异是否会影响对小鼠的毒力。O:4,5,12和O:9,12姐妹组氨酸+转导子源自一株有毒的鼠伤寒沙门氏菌。通过转导引入发酵标记以区分这些菌株，并将这些菌株用作对CF1和C57B1/6J小鼠的混合攻击。攻击后不同时间间隔的小鼠肝脏和脾脏培养表明，对于两种小鼠品系，腹腔攻击后，近等基因对中的O:4,5,12成员比O:9,12成员的增殖程度更高。口服攻击后，CF1小鼠中O:4,5,12和O:9,12菌株的增殖量差异不大，但在C57B1/6J小鼠中，10例中有8例回收的主要菌株是O:4,5,12。
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