吞噬作用在具有O抗原6,7或4,12的鼠伤寒沙门氏菌重组体小鼠毒力中的作用
Role of phagocytosis in mouse virulence of Salmonella typhimurium recombinants with O antigen 6,7 or 4,12.
作者信息
Valtonen M V
出版信息
Infect Immun. 1977 Dec;18(3):574-82. doi: 10.1128/iai.18.3.574-582.1977.
Abstract
The quality of lipopolysaccharide has previously been shown to influence the mouse virulence of Salmonella so that strains with O antigen 4,12 were more virulent than their O-9,12 sister strains. Immunosuppression did not alter this O-antigen-dependent difference in virulence. I have now constructed smooth O-4,12 and O-6,7 sister hybrid strains of Salmonella typhimurium. No other phenotypic differences were found between these strains; they were all "common antigen" positive. In intraperitoneal infection, the O-4,12 strains were more mouse virulent than their O-6,7 sisters. The difference in virulence correlated with a difference in clearance rates; the O-6,7 hybrids were removed from the blood more rapidly than their O-4,12 sisters. No natural bactericidal antibodies were found in the sera of the mice.
摘要
先前已表明脂多糖的质量会影响沙门氏菌对小鼠的毒力，使得具有O抗原4、12的菌株比其O-9、12的姊妹菌株毒力更强。免疫抑制并未改变这种毒力上的O抗原依赖性差异。我现在构建了鼠伤寒沙门氏菌的光滑O-4、12和O-6、7姊妹杂交菌株。这些菌株之间未发现其他表型差异；它们均为“共同抗原”阳性。在腹腔感染中，O-4、12菌株比其O-6、7姊妹菌株对小鼠的毒力更强。毒力差异与清除率差异相关；O-6、7杂交菌株比其O-4、12姊妹菌株从血液中清除得更快。在小鼠血清中未发现天然杀菌抗体。
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本文引用的文献
1
THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY.单核吞噬细胞的分化。形态学、细胞化学与生物化学
J Exp Med. 1965 Jan 1;121(1):153-70. doi: 10.1084/jem.121.1.153.
2
ROUGH MUTANTS OF SALMONELLA TYPHIMURIUM. I. GENETICS.鼠伤寒沙门氏菌的粗糙突变体。I. 遗传学
Nature. 1964 Mar 28;201:1298-9. doi: 10.1038/2011298a0.
3
The complement-dependent bacteriolytic activity of normal human serum. I. The effect of pH and ionic strength and the role of lysozyme.正常人血清的补体依赖性溶菌活性。I. pH值和离子强度的影响以及溶菌酶的作用。
J Exp Med. 1962 Jun 1;115(6):1231-49. doi: 10.1084/jem.115.6.1231.
4
Immunological studies of a heterogenetic enterobacterial antigen (Kunin).一种异源性肠道细菌抗原（库宁）的免疫学研究
J Bacteriol. 1962 Dec;84(6):1245-50. doi: 10.1128/jb.84.6.1245-1250.1962.
5
A quantitative study of the kinetics of blood clearance of P32-labelled Escherichia coli and Staphylococci by the reticuloendothelial system.关于网状内皮系统对P32标记的大肠杆菌和葡萄球菌血液清除动力学的定量研究。
J Exp Med. 1959 Jul 1;110(1):27-48. doi: 10.1084/jem.110.1.27.
6
Studies of a receptor for felix O-1 phage in Salmonella minnesota.明尼苏达沙门氏菌中费利克斯O-1噬菌体受体的研究。
J Gen Microbiol. 1967 Aug;48(2):225-33. doi: 10.1099/00221287-48-2-225.
7
Selective depletion of lymphoid tissue by cyclophosphamide.用环磷酰胺选择性地消耗淋巴组织。
Clin Exp Immunol. 1972 Feb;10(2):285-96.
8
The effect of lipopolysaccharide modification--antigenic factors 1,5,12 2 and 27--on the virulence of salmonella strains for mice.脂多糖修饰——抗原因子1、5、12:2和27——对沙门氏菌菌株对小鼠毒力的影响。
J Gen Microbiol. 1971 Nov;69(1):107-15. doi: 10.1099/00221287-69-1-107.
9
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Eur J Biochem. 1971 Oct 26;22(4):500-5. doi: 10.1111/j.1432-1033.1971.tb01569.x.
10
Mouse virulence of Salmonella strains: the effect of different smooth-type O side-chains.沙门氏菌菌株的小鼠毒力：不同光滑型O侧链的影响。
J Gen Microbiol. 1970 Dec;64(3):255-68. doi: 10.1099/00221287-64-3-255.
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