肠杆菌共同抗原对鼠伤寒沙门氏菌小鼠毒力的影响。
Effect of enterobacterial common antigen on mouse virulence of Salmonella typhimurium.
作者信息
Valtonen M V, Larinkari U M, Plosila M, Valtonen V V, Mäkelä P H
出版信息
Infect Immun. 1976 Jun;13(6):1601-5. doi: 10.1128/iai.13.6.1601-1605.1976.
Abstract
A series of nearly isogenic O4-12, and O-6,7 Salmonella typhimurium strains differing in regard to the enterobacterial common antigen (ECA) were constructed by conjugation. When tested in intraperitoneal infection of mice, the O-4,12 strains containing ECA were more virulent than their O-4,12 sister recombinants without ECA (P = less than 0.001). The same difference could be shown with ECA-positive and ECA-negative S. typhimurium derivatives, whose O antigens were of the group C type (O-6,7). The ECA-positive and ECA-negative O-4,12 strains did not differ in their growth rates in broth or clearance rates in vivo.
摘要
通过接合构建了一系列在肠杆菌共同抗原（ECA）方面存在差异的近等基因鼠伤寒沙门氏菌O4 - 12和O - 6,7菌株。当在小鼠腹腔感染实验中进行测试时，含有ECA的O - 4,12菌株比其不含ECA的O - 4,12姐妹重组体更具毒力（P＜0.001）。对于O抗原为C组类型（O - 6,7）的ECA阳性和ECA阴性鼠伤寒沙门氏菌衍生物，也能显示出同样的差异。ECA阳性和ECA阴性的O - 4,12菌株在肉汤中的生长速率或体内清除率方面没有差异。
相似文献
1
Effect of enterobacterial common antigen on mouse virulence of Salmonella typhimurium.肠杆菌共同抗原对鼠伤寒沙门氏菌小鼠毒力的影响。
Infect Immun. 1976 Jun;13(6):1601-5. doi: 10.1128/iai.13.6.1601-1605.1976.
2
Effect of deletion of gene cluster involved in synthesis of Enterobacterial common antigen on virulence and immunogenicity of live attenuated Salmonella vaccine when delivering heterologous Streptococcus pneumoniae antigen PspA.缺失参与肠杆菌共同抗原合成的基因簇对携带异源肺炎链球菌抗原 PspA 的减毒活沙门氏菌疫苗毒力和免疫原性的影响。
BMC Microbiol. 2020 Jun 8;20(1):150. doi: 10.1186/s12866-020-01837-0.
3
Role of phagocytosis in mouse virulence of Salmonella typhimurium recombinants with O antigen 6,7 or 4,12.吞噬作用在具有O抗原6,7或4,12的鼠伤寒沙门氏菌重组体小鼠毒力中的作用
Infect Immun. 1977 Dec;18(3):574-82. doi: 10.1128/iai.18.3.574-582.1977.
4
The effects of O-antigen character and enterobacterial common antigen content on the in vivo persistence of aromatic-dependent Salmonella sp. live-vaccine strains.O抗原特性和肠杆菌共同抗原含量对芳香族依赖型沙门氏菌活疫苗株体内持久性的影响。
Microb Pathog. 1987 Jul;3(1):31-44. doi: 10.1016/0882-4010(87)90035-0.
5
Enterobacterial common antigen in rfb deletion mutants of Salmonella typhimurium.鼠伤寒沙门氏菌rfb缺失突变体中的肠道细菌共同抗原
J Bacteriol. 1976 Sep;127(3):1141-9. doi: 10.1128/jb.127.3.1141-1149.1976.
6
Enterobacterial common antigen mutants of Salmonella enterica serovar Typhimurium establish a persistent infection and provide protection against subsequent lethal challenge.鼠伤寒沙门氏菌肠杆菌共同抗原突变体能建立持续性感染，并对随后的致死性攻击提供保护。
Infect Immun. 2012 Jan;80(1):441-50. doi: 10.1128/IAI.05559-11. Epub 2011 Oct 24.
7
Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence.肠炎沙门氏菌肠杆菌共同抗原在胆汁抗性和毒力中的作用。
J Bacteriol. 2003 Sep;185(17):5328-32. doi: 10.1128/JB.185.17.5328-5332.2003.
8
Regulated delayed synthesis of lipopolysaccharide and enterobacterial common antigen of Salmonella Typhimurium enhances immunogenicity and cross-protective efficacy against heterologous Salmonella challenge.鼠伤寒沙门氏菌脂多糖和肠杆菌共同抗原的调控延迟合成增强了对异源沙门氏菌攻击的免疫原性和交叉保护效力。
Vaccine. 2016 Aug 5;34(36):4285-92. doi: 10.1016/j.vaccine.2016.07.010.
9
Biosynthesis of enterobacterial common antigen.肠杆菌共同抗原的生物合成
J Bacteriol. 1985 May;162(2):494-503. doi: 10.1128/jb.162.2.494-503.1985.
10
Comparison of the virulence of O:9,12 and O:4,5,12 Salmonella typhimurium his+ transductants for mice.鼠伤寒沙门氏菌O:9,12和O:4,5,12 his+转导子对小鼠毒力的比较。
Infect Immun. 1977 Feb;15(2):491-9. doi: 10.1128/iai.15.2.491-499.1977.
引用本文的文献
1
Recent advances in understanding of enterobacterial common antigen synthesis and regulation.肠道细菌共同抗原合成与调控研究的最新进展。
Open Biol. 2025 Jan;15(7):250055. doi: 10.1098/rsob.250055. Epub 2025 Jul 2.
2
ElyC and Cyclic Enterobacterial Common Antigen Regulate Synthesis of Phosphoglyceride-Linked Enterobacterial Common Antigen.ElyC 和环肠杆菌共同抗原调节磷酯糖连接肠杆菌共同抗原的合成。
mBio. 2021 Dec 21;12(6):e0284621. doi: 10.1128/mBio.02846-21. Epub 2021 Nov 23.
3
Regulated delayed synthesis of lipopolysaccharide and enterobacterial common antigen of Salmonella Typhimurium enhances immunogenicity and cross-protective efficacy against heterologous Salmonella challenge.鼠伤寒沙门氏菌脂多糖和肠杆菌共同抗原的调控延迟合成增强了对异源沙门氏菌攻击的免疫原性和交叉保护效力。
Vaccine. 2016 Aug 5;34(36):4285-92. doi: 10.1016/j.vaccine.2016.07.010.
4
Enterobacterial common antigen mutants of Salmonella enterica serovar Typhimurium establish a persistent infection and provide protection against subsequent lethal challenge.鼠伤寒沙门氏菌肠杆菌共同抗原突变体能建立持续性感染，并对随后的致死性攻击提供保护。
Infect Immun. 2012 Jan;80(1):441-50. doi: 10.1128/IAI.05559-11. Epub 2011 Oct 24.
5
Crystal structure of TDP-fucosamine acetyltransferase (WecD) from Escherichia coli, an enzyme required for enterobacterial common antigen synthesis.来自大肠杆菌的TDP-岩藻糖胺乙酰转移酶（WecD）的晶体结构，该酶是肠道细菌共同抗原合成所必需的。
J Bacteriol. 2006 Aug;188(15):5606-17. doi: 10.1128/JB.00306-06.
6
Role for Salmonella enterica enterobacterial common antigen in bile resistance and virulence.肠炎沙门氏菌肠杆菌共同抗原在胆汁抗性和毒力中的作用。
J Bacteriol. 2003 Sep;185(17):5328-32. doi: 10.1128/JB.185.17.5328-5332.2003.
7
Complement activation by polysaccharide of lipopolysaccharide: an important virulence determinant of salmonellae.脂多糖多糖激活补体：沙门氏菌的一个重要毒力决定因素。
Infect Immun. 1983 Aug;41(2):563-9. doi: 10.1128/iai.41.2.563-569.1983.
8
Test of the virulence and live-vaccine efficacy of auxotrophic and galE derivatives of Salmonella choleraesuis.猪霍乱沙门氏菌营养缺陷型和galE衍生物的毒力及活疫苗效力试验。
Infect Immun. 1987 Apr;55(4):955-62. doi: 10.1128/iai.55.4.955-962.1987.
9
Expression of the cloned Escherichia coli O9 rfb gene in various mutant strains of Salmonella typhimurium.克隆的大肠杆菌O9 rfb基因在鼠伤寒沙门氏菌各种突变菌株中的表达。
J Bacteriol. 1991 Jan;173(1):55-8. doi: 10.1128/jb.173.1.55-58.1991.
10
Linkage map of Salmonella typhimurium, edition V.鼠伤寒沙门氏菌连锁图谱，第五版
Microbiol Rev. 1978 Jun;42(2):471-519. doi: 10.1128/mr.42.2.471-519.1978.
本文引用的文献
1
SEPARATION, CHARACTERIZATION, AND BIOLOGICAL SIGNIFICANCE OF A COMMON ANTIGEN IN ENTEROBACTERIACEAE.肠杆菌科中一种共同抗原的分离、鉴定及生物学意义
J Exp Med. 1963 Oct 1;118(4):565-86. doi: 10.1084/jem.118.4.565.
2
Immunological studies of a heterogenetic enterobacterial antigen (Kunin).一种异源性肠道细菌抗原（库宁）的免疫学研究
J Bacteriol. 1962 Dec;84(6):1245-50. doi: 10.1128/jb.84.6.1245-1250.1962.
3
Sensitivity of rough gram-negative bacteria to the bactericidal action of serum.粗糙革兰氏阴性菌对血清杀菌作用的敏感性。
J Bacteriol. 1968 May;95(5):1647-50. doi: 10.1128/jb.95.5.1647-1650.1968.
4
A new gene cluster rfe concerned with the biosynthesis of Salmonella lipopolysaccharide.一个与沙门氏菌脂多糖生物合成有关的新基因簇rfe。
J Gen Microbiol. 1970 Jan;60(1):91-106. doi: 10.1099/00221287-60-1-91.
5
Genetic determination of the O antigens of Salmonella groups B (4,5,12) and C1(6,7).沙门氏菌B群（4,5,12）和C1群（6,7）O抗原的遗传决定因素。
J Bacteriol. 1966 Mar;91(3):1115-25. doi: 10.1128/jb.91.3.1115-1125.1966.
6
Effect of common enterobacterial antiserum on experimental Salmonella typhimurium infection of mice.普通肠杆菌抗血清对小鼠实验性鼠伤寒沙门氏菌感染的影响。
Proc Soc Exp Biol Med. 1971 Sep;137(4):1209-12. doi: 10.3181/00379727-137-35757.
7
Mouse virulence of Salmonella strains: the effect of different smooth-type O side-chains.沙门氏菌菌株的小鼠毒力：不同光滑型O侧链的影响。
J Gen Microbiol. 1970 Dec;64(3):255-68. doi: 10.1099/00221287-64-3-255.
8
Differences in antibody responses of mouse strains to enterobacterial common antigen.小鼠品系对肠杆菌共同抗原的抗体反应差异。
Proc Soc Exp Biol Med. 1970 Jul;134(3):776-9. doi: 10.3181/00379727-134-34881.
9
Salmonella abony-Salmonella typhimurium recombinant nonvirulent for the mouse.阿博尼沙门氏菌-鼠伤寒沙门氏菌重组体，对小鼠无致病性。
J Bacteriol. 1969 Mar;97(3):1343-51. doi: 10.1128/jb.97.3.1343-1351.1969.
10
Common enterobacterial antigen. 3. Initial titers and antibody response in bacteremia caused by gram-negative bacilli.常见肠道细菌抗原。3. 革兰氏阴性杆菌所致菌血症的初始滴度及抗体反应。
Infect Immun. 1973 Mar;7(3):393-7. doi: 10.1128/iai.7.3.393-397.1973.
Zotero 插件