Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Republic of Korea.
Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Republic of Korea,
Dig Dis. 2020;38(6):507-514. doi: 10.1159/000506938. Epub 2020 Mar 5.
Recently, sarcopenia has been proposed as an additional risk factor of nonalcoholic fatty liver disease (NAFLD), and there have been no studies in patients with inflammatory bowel disease (IBD). We aimed to analyze the clinical associations between sarcopenia and NAFLD in IBD patients.
From January 2004 to December 2017, a total of 488 IBD patients, with CT results, were classified according to the presence of NAFLD. Sarcopenia was assessed based on the muscle volume calculated by the total psoas muscle area in the third lumbar region divided by the square of the patient's height (m2).
Among the 443 included patients, NAFLD was diagnosed in 49 patients (11.1%). Sarcopenia was noted in 34.9%; it was more common in the NAFLD group (51.0 vs. 33.0%; p = 0.019). In multivariate analysis, metabolic syndrome (odds ratio [OR], 8.63), hyperuricemia (OR, 4.66), small bowel resection (OR, 3.45), and sarcopenia (OR, 2.99) were significant risk factors of NAFLD in IBD patients. In addition, sarcopenia was an independent risk factor after adjustment for age, sex, and other metabolic factors (OR, 2.26).
The prevalence of nonalcoholic fatty liver in IBD patients was 11.1%, and sarcopenia was an independent risk factor.
最近，肌少症被提出作为非酒精性脂肪性肝病（NAFLD）的一个附加危险因素，而在炎症性肠病（IBD）患者中尚未进行相关研究。我们旨在分析 IBD 患者中肌少症与 NAFLD 的临床相关性。
2004 年 1 月至 2017 年 12 月，共有 488 例接受 CT 检查的 IBD 患者，根据是否存在 NAFLD 进行分类。通过第三腰椎区域总腰大肌面积除以患者身高的平方（m2）计算的肌肉体积评估肌少症。
在纳入的 443 例患者中，诊断为 NAFLD 的患者有 49 例（11.1%）。肌少症的发生率为 34.9%；在 NAFLD 组更为常见（51.0%比 33.0%；p=0.019）。多变量分析显示，代谢综合征（比值比 [OR]，8.63）、高尿酸血症（OR，4.66）、小肠切除术（OR，3.45）和肌少症（OR，2.99）是 IBD 患者 NAFLD 的显著危险因素。此外，在校正年龄、性别和其他代谢因素后，肌少症仍然是 NAFLD 的独立危险因素（OR，2.26）。
IBD 患者中 NAFLD 的患病率为 11.1%，肌少症是独立危险因素。
