From the Neuroradiology Section (D.P., A.G.-V., M.A., C.A., A.R.)
From the Neuroradiology Section (D.P., A.G.-V., M.A., C.A., A.R.).
AJNR Am J Neuroradiol. 2020 Mar;41(3):461-463. doi: 10.3174/ajnr.A6481. Epub 2020 Mar 5.
The study aim was to compare the ratio of T1WI to T2WI signal intensity (T1/T2) with magnetization transfer ratio, a marker of myelin integrity, in patients with multiple sclerosis. A moderate correlation ( = 0.50, = .034) was found between the magnetization transfer ratio and T1/T2 in normal-appearing gray matter, and a strong correlation for normal-appearing white matter ( = 0.63, = .005) and lesions ( = 0.70, = .001). Results suggest that besides myelin integrity, other factors may be playing a role in T1/T2 measures.
这项研究旨在比较多发性硬化症患者的 T1WI 与 T2WI 信号强度比（T1/T2）与磁化传递率（一种髓鞘完整性的标志物）之间的关系。在正常表现的灰质中，发现磁化传递率与 T1/T2 之间存在中度相关性（r = 0.50，p =.034），而在正常表现的白质和病变中存在较强相关性（r = 0.63，p =.005 和 r = 0.70，p =.001）。结果表明，除了髓鞘完整性之外，其他因素可能在 T1/T2 测量中起作用。
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