Nimeth Barbara Anna, Riegler Stefan, Kalyna Maria
Department of Applied Genetics and Cell Biology, BOKU-University of Natural Resources and Life Sciences, Vienna, Austria.
Front Plant Sci. 2020 Feb 19;11:91. doi: 10.3389/fpls.2020.00091. eCollection 2020.
Plants are exposed to a variety of abiotic and biotic stresses that may result in DNA damage. Endogenous processes - such as DNA replication, DNA recombination, respiration, or photosynthesis - are also a threat to DNA integrity. It is therefore essential to understand the strategies plants have developed for DNA damage detection, signaling, and repair. Alternative splicing (AS) is a key post-transcriptional process with a role in regulation of gene expression. Recent studies demonstrate that the majority of intron-containing genes in plants are alternatively spliced, highlighting the importance of AS in plant development and stress response. Not only does AS ensure a versatile proteome and influence the abundance and availability of proteins greatly, it has also emerged as an important player in the DNA damage response (DDR) in animals. Despite extensive studies of DDR carried out in plants, its regulation at the level of AS has not been comprehensively addressed. Here, we provide some insights into the interplay between AS and DDR in plants.
植物会受到各种非生物和生物胁迫，这些胁迫可能导致DNA损伤。内源性过程——如DNA复制、DNA重组、呼吸作用或光合作用——也对DNA完整性构成威胁。因此，了解植物为DNA损伤检测、信号传导和修复所开发的策略至关重要。可变剪接（AS）是一种关键的转录后过程，在基因表达调控中发挥作用。最近的研究表明，植物中大多数含内含子的基因都进行可变剪接，这凸显了可变剪接在植物发育和胁迫响应中的重要性。可变剪接不仅确保了蛋白质组的多样性并极大地影响蛋白质的丰度和可用性，它在动物的DNA损伤应答（DDR）中也已成为一个重要角色。尽管在植物中对DNA损伤应答进行了广泛研究，但其在可变剪接水平上的调控尚未得到全面探讨。在此，我们对植物中可变剪接与DNA损伤应答之间的相互作用提供一些见解。
