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孕期母体骨吸收受抑制会抑制胎鼠骨骼发育。

Inhibited Maternal Bone Resorption Suppress Fetal Rat Bone Development During Pregnancy.

作者信息

Jia Huanhuan, Rao Li, Miu Kai Kei, Tang Shuangjie, Chen Wei, Yang Guozhu, Li Yuying, Li Qingnan, Chen Jun, Lu Li

机构信息

School of Life Sciences and Biopharmacy, Guangdong Province Key Laboratory for Biotechnology Drug Candidates, Guangdong Pharmaceutical University, Guangzhou, China.

Guangdong Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, Guangzhou, China.

出版信息

Front Cell Dev Biol. 2020 Feb 19;8:83. doi: 10.3389/fcell.2020.00083. eCollection 2020.

DOI:10.3389/fcell.2020.00083
PMID:32140467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7042177/
Abstract

OBJECTIVE

To determine the relationship between maternal bone resorption and bone development in fetuses.

METHODS

Female SD rats were injected with either fluorescent calcium indicator calcein alone or together with tetracycline 1 week before pregnancy, followed by fluorescence detection in fetal tibias 21 days post-treatment. Alendronate was subsequently administered to pregnant rats to inhibit maternal bone resorption, while maternal bone turnover and fetal bone development were both examined.

RESULTS

The maternal fluorescent labeled calcium before pregnancy was found in the fetal tibia. This indicated that the calcium of maternal bones may be released into the maternal circulation through high bone resorption during pregnancy, thereby participating in the fetal bone development. Bone histomorphometry and serum biomarker results showed that Alendronate significantly inhibited maternal bone resorption in pregnant rats when compared to normal pregnant rats. Moreover, the body weight, bone mass, and bone length of the fetuses in the Alendronate group were significantly decreased; while no apparent abnormality in placental morphology was observed. The above results implied that when maternal bone resorption is suppressed, the development of the fetal bone shall also be suppressed.

CONCLUSION

Calcium in the maternal bone is released into the maternal circulation through bone resorption during pregnancy which represents an important material source in fetal bone development. Therefore, high bone turnover during pregnancy is essential for mammalian embryonic bone development.

摘要

目的

确定母体骨吸收与胎儿骨骼发育之间的关系。

方法

雌性SD大鼠在怀孕前1周单独注射荧光钙指示剂钙黄绿素或与四环素一起注射，然后在处理后21天对胎儿胫骨进行荧光检测。随后给怀孕大鼠施用阿仑膦酸盐以抑制母体骨吸收，同时检查母体骨转换和胎儿骨骼发育。

结果

在胎儿胫骨中发现了怀孕前母体荧光标记的钙。这表明母体骨骼中的钙可能在怀孕期间通过高骨吸收释放到母体循环中，从而参与胎儿骨骼发育。骨组织形态计量学和血清生物标志物结果表明，与正常怀孕大鼠相比，阿仑膦酸盐显著抑制了怀孕大鼠的母体骨吸收。此外，阿仑膦酸盐组胎儿的体重、骨量和骨长度显著降低；而胎盘形态未观察到明显异常。上述结果表明，当母体骨吸收受到抑制时，胎儿骨骼的发育也会受到抑制。

结论

母体骨骼中的钙在怀孕期间通过骨吸收释放到母体循环中，这是胎儿骨骼发育的重要物质来源。因此，怀孕期间的高骨转换对哺乳动物胚胎骨骼发育至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/91063016c153/fcell-08-00083-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/fd532c8bf19c/fcell-08-00083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/286e64708e90/fcell-08-00083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/edb8e1d41ab3/fcell-08-00083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/6e0d8c64f21d/fcell-08-00083-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/e443ccad16fd/fcell-08-00083-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/086b2bad1fa4/fcell-08-00083-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/ea192fb8a6e1/fcell-08-00083-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/284a1407eaf0/fcell-08-00083-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/91063016c153/fcell-08-00083-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/fd532c8bf19c/fcell-08-00083-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/286e64708e90/fcell-08-00083-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/edb8e1d41ab3/fcell-08-00083-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/6e0d8c64f21d/fcell-08-00083-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/e443ccad16fd/fcell-08-00083-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/086b2bad1fa4/fcell-08-00083-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/ea192fb8a6e1/fcell-08-00083-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/284a1407eaf0/fcell-08-00083-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/988b/7042177/91063016c153/fcell-08-00083-g009.jpg

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