Wittwehr Clemens, Blomstedt Paul, Gosling John Paul, Peltola Tomi, Raffael Barbara, Richarz Andrea-Nicole, Sienkiewicz Marta, Whaley Paul, Worth Andrew, Whelan Maurice
European Commission, Joint Research Centre (JRC), Ispra, Italy.
Aalto University, Espoo, Finland.
Comput Toxicol. 2020 Feb;13:100114. doi: 10.1016/j.comtox.2019.100114.
As the basis for managing the risks of chemical exposure, the Chemical Risk Assessment (CRA) process can impact a substantial part of the economy, the health of hundreds of millions of people, and the condition of the environment. However, the number of properly assessed chemicals falls short of societal needs due to a lack of experts for evaluation, interference of third party interests, and the sheer volume of potentially relevant information on the chemicals from disparate sources. In order to explore ways in which computational methods may help overcome this discrepancy between the number of chemical risk assessments required on the one hand and the number and adequateness of assessments actually being conducted on the other, the European Commission's Joint Research Centre organised a workshop on Artificial Intelligence for Chemical Risk Assessment (AI4CRA). The workshop identified a number of areas where Artificial Intelligence could potentially increase the number and quality of regulatory risk management decisions based on CRA, involving process simulation, supporting evaluation, identifying problems, facilitating collaboration, finding experts, evidence gathering, systematic review, knowledge discovery, and building cognitive models. Although these are interconnected, they are organised and discussed under two main themes: scientific-technical process and social aspects and the decision making process.
作为管理化学物质暴露风险的基础,化学风险评估(CRA)过程会对经济的很大一部分、数亿人的健康以及环境状况产生影响。然而,由于缺乏评估专家、第三方利益的干扰以及来自不同来源的大量潜在相关化学物质信息,经过恰当评估的化学物质数量无法满足社会需求。为了探索计算方法如何有助于克服一方面所需的化学风险评估数量与另一方面实际进行的评估数量和充分性之间的这种差异,欧盟委员会联合研究中心组织了一次关于化学风险评估人工智能(AI4CRA)的研讨会。该研讨会确定了人工智能可能在多个方面增加基于CRA的监管风险管理决策数量和质量的领域,包括过程模拟、支持评估、识别问题、促进协作、寻找专家、证据收集、系统综述、知识发现以及构建认知模型。尽管这些方面相互关联,但它们是在两个主要主题下进行组织和讨论的:科学技术过程与社会层面以及决策过程。