Brown Ryan L, Shahane Anoushka D, Chen Michelle A, Fagundes Christopher P
Rice University, 6100 Main Street, Houston, TX, 77005, United States.
The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, United States.
Brain Behav Immun Health. 2020 Jan;1. doi: 10.1016/j.bbih.2019.100012. Epub 2019 Nov 18.
Following exposure to the common cold (i.e., rhinovirus), locally produced nasal cytokines (rather than the infection itself) drive the progression of one's symptoms (Hendley et al., 1973; Cohen et al., 1999). Stress-induced local inflammation exacerbates local cytokine production (e.g., marital hostility; Kiecolt-Glaser et al., 2005). An individual's ability to effectively manage their emotions is a critical component of positive health and well-being. Here, we evaluated whether one's self-reported frequency of cognitive reappraisal, an adaptive emotion regulation strategy, predicts nasal cytokine production following experimental rhinovirus exposure. Emotion regulation strategies were assessed at baseline prior to experimental infection. After the baseline assessment, each participant was exposed to a strain of rhinovirus (RV-39) and followed for 5 days in quarantine. Nasal interleukin (IL)-1β, IL-6, and IL-8 and subjective symptoms were assessed at baseline and on each of the 5 days of quarantine. A multilevel analysis of the data for 159 participants with documented infection demonstrated that less frequent use of cognitive reappraisal predicted heightened production of the nasal cytokine composite. Those who self-reported using cognitive reappraisal strategies less frequently displayed elevated nasal IL-6 and IL-8. Among the 63 participants with clinical cold, less frequent use of cognitive reappraisal was associated with heightened production of nasal IL-1β, IL-6, and IL-8. In ancillary analyses, the composite of nasal cytokines was associated with the severity of one's subjective symptoms across the 5 days. Findings suggest that emotion regulation strategies, particularly cognitive reappraisal, influence illness trajectories during rhinovirus infection.
接触普通感冒病毒（即鼻病毒）后，局部产生的鼻腔细胞因子（而非感染本身）会促使症状加重（亨德利等人，1973年；科恩等人，1999年）。压力诱发的局部炎症会加剧局部细胞因子的产生（例如婚姻敌意；基科尔特-格拉泽等人，2005年）。个体有效管理情绪的能力是积极健康和幸福的关键组成部分。在此，我们评估了自我报告的认知重评频率（一种适应性情绪调节策略）是否能预测实验性鼻病毒感染后鼻腔细胞因子的产生。在实验性感染前的基线期评估情绪调节策略。基线评估后，每位参与者接触一株鼻病毒（RV - 39），并在隔离状态下随访5天。在基线期以及隔离的5天中的每一天评估鼻腔白细胞介素（IL）-1β、IL - 6和IL - 8以及主观症状。对159名有感染记录的参与者的数据进行的多层次分析表明，认知重评使用频率较低预示着鼻腔细胞因子复合物的产生增加。那些自我报告较少使用认知重评策略的人鼻腔IL - 6和IL - 8水平升高。在63名患临床感冒的参与者中，认知重评使用频率较低与鼻腔IL - 1β、IL - 6和IL - 8的产生增加有关。在辅助分析中，鼻腔细胞因子复合物与5天内主观症状的严重程度相关。研究结果表明，情绪调节策略，尤其是认知重评，会影响鼻病毒感染期间的疾病发展轨迹。
