Smith Constance M, Kadin James A, Baldarelli Richard M, Beal Jonathan S, Blodgett Olin, Giannatto Sharon C, Richardson Joel E, Ringwald Martin
The Jackson Laboratory 600 Main Street Bar Harbor, ME 04609, USA.
Database (Oxford). 2020 Jan 1;2020. doi: 10.1093/database/baaa002.
The Gene Expression Database (GXD), an extensive community resource of curated expression information for the mouse, has developed an RNA-Seq and Microarray Experiment Search (http://www.informatics.jax.org/gxd/htexp_index). This tool allows users to quickly and reliably find specific experiments in ArrayExpress and the Gene Expression Omnibus (GEO) that study endogenous gene expression in wild-type and mutant mice. Standardized metadata annotations, curated by GXD, allow users to specify the anatomical structure, developmental stage, mutated gene, strain and sex of samples of interest, as well as the study type and key parameters of the experiment. These searches, powered by controlled vocabularies and ontologies, can be combined with free text searching of experiment titles and descriptions. Search result summaries include link-outs to ArrayExpress and GEO, providing easy access to the expression data itself. Links to the PubMed entries for accompanying publications are also included. More information about this tool and GXD can be found at the GXD home page (http://www.informatics.jax.org/expression.shtml). Database URL: http://www.informatics.jax.org/expression.shtml.
基因表达数据库（GXD）是一个关于小鼠的精心整理的表达信息的广泛社区资源，它开发了一个RNA测序和微阵列实验搜索工具（http://www.informatics.jax.org/gxd/htexp_index）。该工具允许用户快速、可靠地在ArrayExpress和基因表达综合数据库（GEO）中找到研究野生型和突变型小鼠内源性基因表达的特定实验。由GXD整理的标准化元数据注释，允许用户指定感兴趣样本的解剖结构、发育阶段、突变基因、品系和性别，以及实验的研究类型和关键参数。这些由受控词汇表和本体驱动的搜索，可以与对实验标题和描述的自由文本搜索相结合。搜索结果摘要包括指向ArrayExpress和GEO的链接，便于访问表达数据本身。还包括指向相关出版物的PubMed条目的链接。有关此工具和GXD的更多信息，请访问GXD主页（http://www.informatics.jax.org/expression.shtml）。数据库网址：http://www.informatics.jax.org/expression.shtml 。
