Department of Biochemistry & Molecular Biology, Medical College, University of South China, Hengyang, 421001, Hunan, China.
Department of Clinical Laboratory, The First Affiliated Hospital, University of South China, Hengyang, 421001, Hunan, China.
J Membr Biol. 2020 Apr;253(2):101-108. doi: 10.1007/s00232-020-00110-9. Epub 2020 Mar 5.
As a member of the kinesin-3 family, kinesin family member 16B (KIF16B) has a characteristic PhoX homology (PX) domain that binds to membranes containing phosphatidylinositol-3-phosphate (PI(3)P) and moves along microtubule filaments to the plus end via a process regulated by coiled coils in the stalk region in various cell types. The physiological function of KIF16B supports the transport of intracellular cargo and the formation of endosomal tubules. Ras-related protein (Rab) coordinates many steps of membrane transport and are involved in the regulation of KIF16B-mediated vesicle trafficking. Data obtained from clinical research suggest that KIF16B has a potential effect on the disease processes in intellectual disability, abnormal lipid metabolism, and tumor brain metastasis. In this review, we summarize recent advances in the structural and physiological characteristics of KIF16B as well as diseases associated with KIF16B disorders, and speculating its role as a potential adaptor for intracellular cholesterol trafficking.
作为驱动蛋白-3 家族的一员，驱动蛋白家族成员 16B（KIF16B）具有特征性的 PhoX 同源（PX）结构域，该结构域可以与含有磷脂酰肌醇-3-磷酸（PI(3)P）的膜结合，并通过卷曲螺旋在 stalk 区域的调节下沿着微管丝向正极移动，该过程在各种细胞类型中发生。KIF16B 的生理功能支持细胞内货物的运输和内体小管的形成。Ras 相关蛋白（Rab）协调膜运输的许多步骤，并参与调节 KIF16B 介导的囊泡运输。从临床研究中获得的数据表明，KIF16B 可能对智力障碍、脂质代谢异常和肿瘤脑转移等疾病过程产生影响。在这篇综述中，我们总结了 KIF16B 的结构和生理特性以及与 KIF16B 紊乱相关疾病的最新进展，并推测其作为细胞内胆固醇运输的潜在衔接蛋白的作用。
