Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, 150040, P. R. China.
Chem Biodivers. 2020 Apr;17(4):e2000035. doi: 10.1002/cbdv.202000035. Epub 2020 Apr 6.
Fifteen constituents, including one new lignan (schisandroside E) and one new terpenoid (schisandenoid A) as well as nine known lignans and four known terpenoids, were isolated from Schisandra chinensis leaves. The structures of schisandroside E and schisandenoid A were established by entirely meticulous spectroscopic analysis (NMR, MS, CD, IR and UV). All compounds were tested for cytotoxicity against MGC-803, Caco-2 and Ishikawa cell lines. Some compounds showed strong cytotoxicity against these three cancer cell lines with IC <1 μm.
从五味子叶中分离得到 15 个成分，包括一个新的木脂素（五味子酯 E）和一个新的萜类（五味子烯 A），以及 9 个已知的木脂素和 4 个已知的萜类。通过全细致的光谱分析（NMR、MS、CD、IR 和 UV）确定了五味子酯 E 和五味子烯 A 的结构。所有化合物均进行了对 MGC-803、Caco-2 和 Ishikawa 细胞系的细胞毒性测试。一些化合物对这三种癌细胞系表现出很强的细胞毒性，IC <1 μm。
