Zhang Qing, Hou Dan, Wen Xueying, Xin Mengyu, Li Ziling, Wu Lihong, Pathak Janak L
Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, 510182, China.
Laboratory for Myology, Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, 1081 BT Amsterdam, the Netherlands.
Mater Today Bio. 2022 Jun 22;15:100333. doi: 10.1016/j.mtbio.2022.100333. eCollection 2022 Jun.
Early diagnosis and treatment of oral cancer are vital for patient survival. Since the oral cavity accommodates the second largest and most diverse microbiome community after the gut, the diagnostic and therapeutic approaches with low invasiveness and minimal damage to surrounding tissues are keys to preventing clinical intervention-related infections. Gold nanoparticles (AuNPs) are widely used in the research of cancer diagnosis and therapy due to their excellent properties such as surface-enhanced Raman spectroscopy, surface plasma resonance, controlled synthesis, the plasticity of surface morphology, biological safety, and stability. AuNPs had been used in oral cancer detection reagents, tumor-targeted therapy, photothermal therapy, photodynamic therapy, and other combination therapies for oral cancer. AuNPs-based noninvasive diagnosis and precise treatments further reduce the clinical intervention-related infections. This review is focused on the recent advances in research and application of AuNPs for early screening, diagnostic typing, drug delivery, photothermal therapy, radiotherapy sensitivity treatment, and combination therapy of oral cancer. Distinctive reports from the literature are summarized to highlight the latest advances in the development and application of AuNPs in oral cancer diagnosis and therapy. Finally, this review points out the challenges and prospects of possible applications of AuNPs in oral cancer diagnosis and therapy.
口腔癌的早期诊断和治疗对患者的生存至关重要。由于口腔是继肠道之后容纳第二大且最多样化微生物群落的部位，具有低侵入性且对周围组织损伤最小的诊断和治疗方法是预防临床干预相关感染的关键。金纳米颗粒（AuNPs）因其具有表面增强拉曼光谱、表面等离子体共振、可控合成、表面形态可塑性、生物安全性和稳定性等优异特性，而被广泛应用于癌症诊断和治疗的研究中。AuNPs已被用于口腔癌检测试剂、肿瘤靶向治疗、光热治疗、光动力治疗以及其他口腔癌联合治疗中。基于AuNPs的非侵入性诊断和精准治疗进一步减少了临床干预相关感染。本综述聚焦于AuNPs在口腔癌早期筛查、诊断分型、药物递送、光热治疗、放射增敏治疗及联合治疗等方面研究与应用的最新进展。总结了文献中的特色报道，以突出AuNPs在口腔癌诊断和治疗方面开发与应用的最新进展。最后，本综述指出了AuNPs在口腔癌诊断和治疗中可能应用所面临的挑战与前景。
