Ahmad Iftikhar, Khaliq Ahmar, Iqbal Muaz, Khan Shamim
Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar, Pakistan.
Department of Physics, Islamia College Peshawar, Khyber Pakhtunkhwa, Pakistan.
Photodiagnosis Photodyn Ther. 2020 Jun;30:101708. doi: 10.1016/j.pdpdt.2020.101708. Epub 2020 Mar 4.
Mueller matrix polarimetry (MMP) has emerged as a simple, fast and non-invasive optical tool in basic and preclinical research whereby polarized light measurements are used to characterize biological samples. The skin tissue being exposed can be easily sampled, and the highly anisotropic nature of its ultra-structural components (e.g., the dense collagen/ elastin matrix, fibers) enable it a particularly suitable site for MMP investigations. In this study, we aim to survey, summarize, analyze and speculate on the trends in the literature which deals with the MMP of skin tissues. Specifically, we start with a brief description of the experimental implementation of MMP technique, with a focus on both the hardware and methodology, followed by a comprehensive online literature survey to summarize the MMP data pertaining to skin tissues and associated pathologies. Finally, the polarimetric data of skin tissues have been analyzed, quantitatively compared (using box and whisker plot and student t test) and the observed trends interpreted with the help of tissue morphology. We expect that this work will provide a useful reference to a comprehensive MMP analysis of the skin tissues.
穆勒矩阵偏振测量法（MMP）已成为基础研究和临床前研究中一种简单、快速且无创的光学工具，通过偏振光测量来表征生物样品。暴露的皮肤组织易于取样，其超微结构成分（如致密的胶原蛋白/弹性蛋白基质、纤维）的高度各向异性使其成为MMP研究的特别合适部位。在本研究中，我们旨在调查、总结、分析和推测涉及皮肤组织MMP的文献趋势。具体而言，我们首先简要描述MMP技术的实验实施，重点关注硬件和方法，然后进行全面的在线文献调查，以总结与皮肤组织及相关病理学有关的MMP数据。最后，对皮肤组织的偏振数据进行了分析、定量比较（使用箱线图和学生t检验），并借助组织形态学对观察到的趋势进行了解释。我们期望这项工作将为皮肤组织的全面MMP分析提供有用的参考。
