School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, United States; Emory-Children's Cystic Fibrosis Center, Atlanta, GA 30332, United States; Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, GA 30332, United States.
School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, United States; Emory-Children's Cystic Fibrosis Center, Atlanta, GA 30332, United States; Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, GA 30332, United States.
Curr Opin Microbiol. 2020 Feb;53:44-50. doi: 10.1016/j.mib.2020.02.003. Epub 2020 Mar 4.
Chronic infections place a significant burden on healthcare systems, requiring over $25 billion in treatment annually in the United States alone [1,2]. Notably, the majority of chronic infections, which include cystic fibrosis (CF), chronic wounds, otitis media, periodontitis, urinary tract infections, and osteomyelitis, are considered polymicrobial and are often recalcitrant to antibiotic treatment [1-9]. Although we know that diverse communities of microbes comprise these infections, how microbes interact and the impacts of these interactions on human disease are less understood. Here, we discuss recent advances in our understanding of how bacteria communicate in chronic infection, with a focus on Staphylococcus aureus and Pseudomonas aeruginosa, and we highlight outstanding questions and controversies in the field.
慢性感染给医疗保健系统带来了巨大负担，仅在美国每年就需要超过 250 亿美元的治疗费用[1,2]。值得注意的是，大多数慢性感染，包括囊性纤维化（CF）、慢性伤口、中耳炎、牙周炎、尿路感染和骨髓炎，被认为是多微生物的，并且经常对抗生素治疗有抗药性[1-9]。尽管我们知道这些感染是由不同种类的微生物组成的，但我们对微生物如何相互作用以及这些相互作用对人类疾病的影响了解甚少。在这里，我们讨论了我们对慢性感染中细菌如何相互交流的理解的最新进展，重点是金黄色葡萄球菌和铜绿假单胞菌，并强调了该领域的悬而未决的问题和争议。
