Diggle Stephen P, Whiteley Marvin
Center for Microbial Dynamics & Infection, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Microbiology (Reading). 2020 Jan;166(1):30-33. doi: 10.1099/mic.0.000860.
is a Gram-negative opportunistic pathogen and a model bacterium for studying virulence and bacterial social traits. While it can be isolated in low numbers from a wide variety of environments including soil and water, it can readily be found in almost any human/animal-impacted environment. It is a major cause of illness and death in humans with immunosuppressive and chronic conditions, and infections in these patients are difficult to treat due to a number of antibiotic resistance mechanisms and the organism's propensity to form multicellular biofilms.
是一种革兰氏阴性机会致病菌,也是研究毒力和细菌社会特性的模式细菌。虽然它可以在包括土壤和水在内的各种环境中少量分离出来,但在几乎任何受人类/动物影响的环境中都很容易找到。它是免疫抑制和慢性疾病患者发病和死亡的主要原因,由于多种抗生素耐药机制以及该生物体形成多细胞生物膜的倾向,这些患者的感染很难治疗。