Demkovych Andrii
Department of Prosthetic Dentistry, Ivan Horbachevsky Ternopil State Medical University, Ternopil, Ukraine.
Interv Med Appl Sci. 2019 Mar;11(1):55-59. doi: 10.1556/1646.10.2018.48.
The article presents the results of lipid peroxidation activity in blood serum, which were assessed on the base changes in the level of oxidative modification of proteins, TBA-active products, and total amount of nitrogen (II) oxide metabolites (NO + NO ). Indices were determined on the 14 day of development in experimental periodontitis both without correction, and in condition treatment with a water-soluble flavonol quercetin (corvitin). The treated animals take intramuscular injections of corvitin in a dose 100 mg/kg weight for 7 days. For further testing, blood serum was selected. The results were statistically analyzed using parametric and non-parametric indices. In this investigation, characterized dynamics of changes in the indices of oxidative processes activity were revealed both during the period of formation and the course of periodontitis. In particular, it was found that, for the period of the most expressed inflammatory reaction in the periodontal complex, intensive increase in the level of reactive forms of oxygen. The treatment with flavonol quercetin for 7 days resulted in stabilization of free radical processes and the suppression of the inflammatory reaction.
本文介绍了血清中脂质过氧化活性的结果，这些结果是根据蛋白质氧化修饰水平、TBA活性产物以及一氧化氮（II）代谢物总量（NO + NO ）的变化来评估的。在实验性牙周炎发展的第14天，在未进行校正以及用水溶性黄酮醇槲皮素（corvitin）治疗的情况下测定各项指标。接受治疗的动物以100 mg/kg体重的剂量肌肉注射corvitin，持续7天。选取血清用于进一步检测。使用参数和非参数指标对结果进行统计学分析。在这项研究中，揭示了在牙周炎形成期和病程中氧化过程活性指标变化的特征动态。特别是，发现在牙周复合体炎症反应最明显的时期，活性氧形式的水平急剧增加。用黄酮醇槲皮素治疗7天导致自由基过程稳定并抑制了炎症反应。
