Demkovych Andrii, Bondarenko Yurii, Hasiuk Petro
Department of Orthopedic Dentistry, I. Ya. Horbachevsky Ternopil State Medical University of the Public Health Ministry of Ukraine, Ternopil, Ukraine.
Department of Pathophysiology, I. Ya. Horbachevsky Ternopil State Medical University of the Public Health Ministry of Ukraine, Ternopil, Ukraine.
Interv Med Appl Sci. 2019 Mar;11(1):60-64. doi: 10.1556/1646.11.2019.06.
The results of experimental research of antioxidant system are presented in this article. Superoxide dismutase activity, catalase, and ceruloplasmin have been determined on the 7 and 14 days of experimental periodontitis development both without correction and with the injection of a water-soluble quercetin drug (corvitin). Hence, there was a decrease in superoxide dismutase activity, intensive increase in catalase activity, and ceruloplasmin maintenance in the blood serum during acute period of inflammatory process. The usage of flavonoid for 7 days resulted in stabilization of radical oxidation due to reduction of superoxide dismutase activity, maintenance at the high-level catalase activity, and ceruloplasmin concentration in the rat's blood plasma with experimental bacterial-immune periodontitis.
本文介绍了抗氧化系统的实验研究结果。在实验性牙周炎发展的第7天和第14天，分别在未进行校正以及注射水溶性槲皮素药物（抗坏血酸）的情况下，测定了超氧化物歧化酶活性、过氧化氢酶和铜蓝蛋白。因此，在炎症过程的急性期，血清中超氧化物歧化酶活性降低，过氧化氢酶活性强烈增加，铜蓝蛋白维持不变。在患有实验性细菌免疫性牙周炎的大鼠血浆中，连续7天使用类黄酮可使自由基氧化稳定，这是由于超氧化物歧化酶活性降低、过氧化氢酶活性维持在高水平以及铜蓝蛋白浓度所致。
