Institute of Cell Biology, University of Bern, Bern, Switzerland.
Instituto de Medicina Molecular - João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Cell Microbiol. 2020 Jun;22(6):e13201. doi: 10.1111/cmi.13201. Epub 2020 Apr 5.
Infections with protozoan and helminthic parasites affect multiple organs in the mammalian host. Imaging pathogens in their natural environment takes a more holistic view on biomedical aspects of parasitic infections. Here, we focus on selected organs of the thoracic and abdominopelvic cavities most commonly affected by parasites. Parasitic infections of these organs are often associated with severe medical complications or have health implications beyond the infected individual. Intravital imaging has provided a more dynamic picture of the host-parasite interplay and contributed not only to our understanding of the various disease pathologies, but has also provided fundamental insight into the biology of the parasites.
原生动物和蠕虫寄生虫的感染会影响哺乳动物宿主的多个器官。在其自然环境中对病原体进行成像，更全面地了解寄生虫感染的生物医学方面。在这里，我们重点关注胸部和腹盆腔中最常受寄生虫影响的选定器官。这些器官的寄生虫感染通常与严重的医疗并发症有关，或者对感染者以外的人有健康影响。活体成像提供了宿主-寄生虫相互作用的更动态的图像，并不仅有助于我们了解各种疾病病理学，而且还为寄生虫的生物学提供了基本的见解。
