Contipro a.s., R&D Department, 561 02 Dolni Dobrouc, Czech Republic.
Department of Composites and Carbon Materials, Institute of Rock Structure and Mechanics, Czech Academy of Sciences, 182 09 Prague 8, Czech Republic.
Molecules. 2020 Mar 5;25(5):1173. doi: 10.3390/molecules25051173.
A composite nanofibrous layer containing collagen and hydroxyapatite was deposited on selected surface areas of titanium acetabular cups. The layer was deposited on the irregular surface of these 3D objects using a specially developed electrospinning system designed to ensure the stability of the spinning process and to produce a layer approximately 100 micrometers thick with an adequate thickness uniformity. It was verified that the layer had the intended nanostructured morphology throughout its entire thickness and that the prepared layer sufficiently adhered to the smooth surface of the model titanium implants even after all the post-deposition sterilization and stabilization treatments were performed. The resulting layers had an average thickness of (110 ± 30) micrometers and an average fiber diameter of (170 ± 49) nanometers. They were produced using a relatively simple and cost-effective technology and yet they were verifiably biocompatible and structurally stable. Collagen- and hydroxyapatite-based composite nanostructured surface modifications represent promising surface treatment options for metal implants.
在选定的钛髋臼杯表面区域沉积了含有胶原和羟基磷灰石的复合纳米纤维层。该层是使用专门开发的静电纺丝系统沉积在这些 3D 物体的不规则表面上的，该系统旨在确保纺丝过程的稳定性，并生产出厚度约为 100 微米且具有足够厚度均匀性的层。已经验证了该层在整个厚度上都具有预期的纳米结构形态，并且即使在进行了所有的后沉积灭菌和稳定化处理之后，制备的层也足以牢固地附着在模型钛植入物的光滑表面上。所得的层的平均厚度为（110±30）微米，平均纤维直径为（170±49）纳米。它们是使用相对简单且具有成本效益的技术生产的，但已被证明具有生物相容性和结构稳定性。基于胶原和羟基磷灰石的复合纳米结构表面改性代表了金属植入物有前途的表面处理选择。
