水凝胶涂层对钛植入物表面改性的研究进展
Progress in Surface Modification of Titanium Implants by Hydrogel Coatings.
作者信息
Chen Huangqin, Feng Rui, Xia Tian, Wen Zhehan, Li Qing, Qiu Xin, Huang Bin, Li Yuesheng
机构信息
Department of Stomatology, School of Stomatology and Ophthalmology, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.
Hubei Key Laboratory of Radiation Chemistry and Functional Materials, Non-Power Nuclear Technology Collaborative Innovation Center, Hubei University of Science and Technology, Xianning 437100, China.
出版信息
Gels. 2023 May 18;9(5):423. doi: 10.3390/gels9050423.
Although titanium and titanium alloys have become the preferred materials for various medical implants, surface modification technology still needs to be strengthened in order to adapt to the complex physiological environment of the human body. Compared with physical or chemical modification methods, biochemical modification, such as the introduction of functional hydrogel coating on implants, can fix biomolecules such as proteins, peptides, growth factors, polysaccharides, or nucleotides on the surface of the implants, so that they can directly participate in biological processes; regulate cell adhesion, proliferation, migration, and differentiation; and improve the biological activity on the surface of the implants. This review begins with a look at common substrate materials for hydrogel coatings on implant surfaces, including natural polymers such as collagen, gelatin, chitosan, and alginate, and synthetic materials such as polyvinyl alcohol, polyacrylamide, polyethylene glycol, and polyacrylic acid. Then, the common construction methods of hydrogel coating (electrochemical method, sol-gel method and layer-by-layer self-assembly method) are introduced. Finally, five aspects of the enhancement effect of hydrogel coating on the surface bioactivity of titanium and titanium alloy implants are described: osseointegration, angiogenesis, macrophage polarization, antibacterial effects, and drug delivery. In this paper, we also summarize the latest research progress and point out the future research direction. After searching, no previous relevant literature reporting this information was found.
尽管钛及钛合金已成为各种医用植入物的首选材料,但为了适应人体复杂的生理环境,表面改性技术仍需加强。与物理或化学改性方法相比,生化改性,如在植入物上引入功能性水凝胶涂层,可以将蛋白质、肽、生长因子、多糖或核苷酸等生物分子固定在植入物表面,使其能够直接参与生物过程;调节细胞黏附、增殖、迁移和分化;并提高植入物表面的生物活性。本文首先介绍了植入物表面水凝胶涂层的常见基底材料,包括天然聚合物如胶原蛋白、明胶、壳聚糖和海藻酸盐,以及合成材料如聚乙烯醇、聚丙烯酰胺、聚乙二醇和聚丙烯酸。然后,介绍了水凝胶涂层的常见构建方法(电化学方法、溶胶 - 凝胶法和层层自组装法)。最后,描述了水凝胶涂层对钛及钛合金植入物表面生物活性增强作用的五个方面:骨整合、血管生成、巨噬细胞极化、抗菌作用和药物递送。在本文中,我们还总结了最新的研究进展并指出了未来的研究方向。经检索,未发现以前有报道此信息的相关文献。