kisspeptin 作为一种潜在的妊娠标志物。
Kisspeptin as a potential biomarker throughout pregnancy.
机构信息
Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China; Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Ministry of Education, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.
出版信息
Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:261-266. doi: 10.1016/j.ejogrb.2019.07.016. Epub 2019 Jul 16.
Kisspeptins are a family of neuropeptides that are critical for the puberty initiation and female fertility. Plasma or serum kisspeptin is mainly derived from the placenta during pregnancy and plasma kisspeptin levels significantly increase across pregnancy. Plasma kisspeptin levels could be used as a potential biomarker for the detection of miscarriage, pre-eclampsia, gestational trophoblastic neoplasia (GTN), and fetal development. Kisspeptin may also be involved in the process of parturition by stimulating oxytocin secretion during term pregnancy. This review discussed the potential use of kisspeptin as a marker across pregnancy and highlighted the unresolved problems in this area. Tweetable abstract: Plasma kisspeptin levels could be used as a potential biomarker across pregnancy.
kisspeptin 是一类神经肽，对于青春期启动和女性生育能力至关重要。血浆或血清 kisspeptin 主要来源于妊娠期间的胎盘，且妊娠期间血浆 kisspeptin 水平显著增加。血浆 kisspeptin 水平可作为检测流产、子痫前期、妊娠滋养细胞肿瘤 (GTN) 和胎儿发育的潜在生物标志物。 kisspeptin 也可能通过在足月妊娠期间刺激催产素分泌而参与分娩过程。本综述讨论了 kisspeptin 在整个孕期作为标志物的潜在用途，并强调了该领域尚未解决的问题。 可推文摘要：血浆 kisspeptin 水平可作为整个孕期的潜在生物标志物。
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