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用于加速伤口愈合的聚合物蠕虫状纳米胶束系统

Polymeric worm-like nanomicellar system for accelerated wound healing.

作者信息

Singh Aarti, Shakeel Adeeba, Kochhar Dakshi, Jeevanandham Sampathkumar, Rajput Satyendra Kumar, Mukherjee Monalisa

机构信息

Amity Institute of Click Chemistry Research and Studies, Amity University, Noida, Uttar Pradesh, India.

All India Institute of Medical Sciences, New Delhi, India.

出版信息

J Adv Pharm Technol Res. 2020 Jan-Mar;11(1):36-43. doi: 10.4103/japtr.JAPTR_153_19.

DOI:10.4103/japtr.JAPTR_153_19
PMID:32154157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7034177/
Abstract

Self-assembly is an unparalleled step in designing macromolecular analogs of nature's simple amphiphiles. Tailoring hydrogel systems - a material with ample potential for wound healing applications - to simultaneously alleviate infection and prompt wound closure is vastly appealing. The poly (DEAEMA-co-AAc) (PDEA) is examined with a cutaneous excisional wound model alterations in wound size, and histological assessments revealed a higher wound healing rate, including dermis proliferation, re-epithelialization, reduced scar formation, and anti-inflammatory properties. Moreover, a mechanism for the formation of spherical and worm-like micelles (WLMs) is delineated using a suite of characterizations. The excellent porosity and ability to absorb exudates impart the PDEA with reliable wound healing. Altogether, this system demonstrates exceptional promise as an infection-mitigating, cell-stimulating, homeostasis-maintaining dressing for accelerated wound healing. The aim and objective of this study is to understand the mechanism of self-assembly in synthesized WLMs from PDEA and their application in wound healing.

摘要

自组装是设计自然界简单两亲分子的大分子类似物时无与伦比的一步。定制水凝胶系统——一种在伤口愈合应用中具有巨大潜力的材料——以同时减轻感染并促进伤口闭合极具吸引力。使用皮肤切除伤口模型对聚（二乙氨基乙基甲基丙烯酸酯 - 共 - 丙烯酸）（PDEA）进行了研究，伤口大小的变化以及组织学评估显示出更高的伤口愈合率，包括真皮增殖、重新上皮化、减少疤痕形成以及抗炎特性。此外，使用一系列表征描绘了球形和蠕虫状胶束（WLM）的形成机制。优异的孔隙率和吸收渗出液的能力赋予了PDEA可靠的伤口愈合性能。总之，该系统作为一种减轻感染、刺激细胞、维持内环境稳定以加速伤口愈合的敷料展现出了非凡的前景。本研究的目的是了解由PDEA合成的WLM中的自组装机制及其在伤口愈合中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b2/7034177/4b1bf3def0a1/JAPTR-11-36-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b2/7034177/935c32c1847d/JAPTR-11-36-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b2/7034177/c2e0fd343a18/JAPTR-11-36-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b2/7034177/22a555621492/JAPTR-11-36-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42b2/7034177/935c32c1847d/JAPTR-11-36-g011.jpg
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本文引用的文献

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