Arafa Mohamed, Agarwal Ashok, Majzoub Ahmad, Panner Selvam Manesh Kumar, Baskaran Saradha, Henkel Ralf, Elbardisi Haitham
Male Infertility Unit, Urology Department, Hamad General Hospital, 00974 Doha, Qatar.
Urology Department, Weill Cornell Medical-Qatar, 00974 Doha, Qatar.
Antioxidants (Basel). 2020 Mar 6;9(3):219. doi: 10.3390/antiox9030219.
Antioxidants are used in the empirical treatment of infertile men. The aim of this study was to evaluate the effects of antioxidant therapy on conventional semen parameters and advanced sperm function tests in men seeking fertility treatment. A total of 148 infertile men of unknown etiology were divided into idiopathic ( = 119) and unexplained male infertility (UMI; = 29). All participants were treated with the antioxidant supplement 'FH PRO for Men' for a period of three months. Compared with pretreatment results, there was a significant improvement in conventional semen parameters including sperm concentration, total and progressive motility and normal morphology, and seminal oxidation reduction potential (ORP), and sperm DNA fragmentation (SDF) in idiopathic infertile men. The changes were more prominent in idiopathic infertile men positive for ORP and SDF. UMI patients showed an improvement in progressive motility, ORP, and SDF after antioxidant treatment. Statistical analysis revealed that the efficacy of FH PRO for Men was significant in idiopathic male infertility compared with UMI. Treatment of idiopathic male infertility patients with the FH PRO for Men antioxidant regimen for three months resulted in a significant improvement in conventional semen parameters and sperm function. Therefore, FH PRO for Men offers promise for the medical treatment of idiopathic male infertility.
抗氧化剂用于男性不育症的经验性治疗。本研究的目的是评估抗氧化剂疗法对寻求生育治疗的男性的常规精液参数和精子高级功能测试的影响。共有148名病因不明的不育男性被分为特发性（n = 119）和不明原因男性不育（UMI；n = 29）。所有参与者均接受抗氧化剂补充剂“男性FH PRO”治疗三个月。与治疗前结果相比，特发性不育男性的常规精液参数包括精子浓度、总活力和前向运动能力以及正常形态、精液氧化还原电位（ORP）和精子DNA碎片率（SDF）均有显著改善。这些变化在ORP和SDF呈阳性的特发性不育男性中更为明显。UMI患者在抗氧化剂治疗后前向运动能力、ORP和SDF有所改善。统计分析显示，与UMI相比，男性FH PRO在特发性男性不育症中的疗效显著。用男性FH PRO抗氧化方案治疗特发性男性不育症患者三个月，可使常规精液参数和精子功能得到显著改善。因此，男性FH PRO为特发性男性不育症的医学治疗带来了希望。
