Department of Otorhinolaryngology and Head and Neck Surgery, HDF Medical Centre, H-1134 Budapest, Hungary.
Department of Otorhinolaryngology and Head and Neck Surgery, Jahn Ferenc Hospital, H-1204 Budapest, Hungary.
Int J Environ Res Public Health. 2020 Mar 7;17(5):1742. doi: 10.3390/ijerph17051742.
The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) may be useful for drawing conclusions about the survival of head and neck squamous cell carcinoma (HNSCC) patients.
Clinical data of 156 patients managed for HNSCC at two head and neck surgery centres were analyzed retrospectively. We studied the relationships between survival and PLR as well as NLR.
With regards to 5-year survival, the difference between the two groups with PLR values lower or higher than the threshold was statistically significant ( = 0.004), and we found the same for disease-free survival ( = 0.05), and tumour-specific mortality ( = 0.009). Concerning NLR, the difference in tumour-specific survival was statistically significant ( = 0.006). According to the multivariate analysis, NLR values higher than the threshold indicated an enhanced risk for overall as well as for tumour-specific mortality.
In HNSCC patients, a high NLR may be considered as an independent risk factor for 5-year overall survival.
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）可用于推断头颈部鳞状细胞癌（HNSCC）患者的生存情况。
回顾性分析了在两个头颈外科中心接受 HNSCC 治疗的 156 名患者的临床数据。我们研究了生存与 PLR 和 NLR 之间的关系。
就 5 年生存率而言，PLR 值低于或高于临界值的两组之间存在统计学差异（=0.004），无病生存率（=0.05）和肿瘤特异性死亡率（=0.009）也是如此。对于 NLR，肿瘤特异性生存率的差异具有统计学意义（=0.006）。根据多变量分析，高于临界值的 NLR 值表明总生存率和肿瘤特异性死亡率的风险增加。
在 HNSCC 患者中，高 NLR 可被视为 5 年总生存率的独立危险因素。
