GREEN GRC-01 UPMC: Group of clinical REsEarch in Neurourology, faculté de médecine, Sorbonne Unviersité, hôpital universitaire Tenon, Assistance publique-Hôpitaux de Paris, 4, rue de la Chine, 75020 Paris, France.
GREEN GRC-01 UPMC: Group of clinical REsEarch in Neurourology, faculté de médecine, Sorbonne Unviersité, hôpital universitaire Tenon, Assistance publique-Hôpitaux de Paris, 4, rue de la Chine, 75020 Paris, France.
Prog Urol. 2020 Jun;30(7):390-395. doi: 10.1016/j.purol.2020.02.006. Epub 2020 Mar 7.
Beside motor control alteration and tremor, the main symptoms in Parkinsonian disorders, lower urinary tract dysfunction is very common and thus often associated with gait disorder. No studies have assessed their association yet. The aim of this study was to assess the effect of the need to void on walking speed in this particular population. The secondary aim was to assess the effect of desire to void in a double task condition on the walking speed, and on the time to raise up from the floor.
This prospective study included all Parkinsonian disorders who had a follow-up for overactive bladder (OAB). We invited them to drink until a desire to void or equivalent (DV), then they performed three ten-meters walk tests, one double-task ten-meters walk test, one timed-up-and-go test (TUG), one timed raise of the floor (GMT). We repeated the same tests just after bladder emptying.
Nine men and two women (age 69±6) were included in the study (seven Parkinson's Diseases, two multisystem atrophies, two not yet characterized). Mean scores of UPDRS-III were 17±6.5, Hoehn & Yahr scale were 1.9±0.7, time since onset 7±4.4 years, levodopa daily equivalent 691±478mg. Patients performed the walking tests at DV with a mean bladder volume from 220±189mL. The mean speed was 1m/s at DV and 1.1m/s at PV (P<0.001). TUG was also increased for patients at DV: mean 9.8 s at DV versus 8.8sec at PV (P<0.003).
In Parkinsonian disorders, need to void may impact the walking speed, a strong desire to void worsening gait velocity.
除了运动控制改变和震颤外，帕金森病患者的主要症状还有下尿路功能障碍，这很常见，因此常与步态障碍有关。目前还没有研究评估它们之间的关系。本研究的目的是评估在这一特定人群中，排尿需求对行走速度的影响。次要目的是评估在双重任务条件下，排尿欲望对行走速度和从地板上抬起的时间的影响。
这项前瞻性研究包括所有接受过膀胱过度活动症（OAB）随访的帕金森病患者。我们邀请他们喝水，直到有排尿的欲望或等效（DV），然后他们进行了三次 10 米步行测试、一次双重任务 10 米步行测试、一次计时起立行走测试（TUG）、一次计时地板抬起测试（GMT）。排空膀胱后，我们重复了同样的测试。
9 名男性和 2 名女性（年龄 69±6 岁）纳入研究（7 名帕金森病患者，2 名多系统萎缩症患者，2 名尚未明确诊断）。UPDRS-III 的平均评分为 17±6.5，Hoehn & Yahr 量表为 1.9±0.7，发病时间为 7±4.4 年，左旋多巴日等效剂量为 691±478mg。患者在 DV 时进行行走测试，平均膀胱容量为 220±189ml。平均速度为 DV 时 1m/s，PV 时 1.1m/s（P<0.001）。在 DV 时，TUG 也增加了患者的测试时间：平均为 9.8 秒在 DV 与 8.8 秒在 PV（P<0.003）。
在帕金森病患者中，排尿需求可能会影响行走速度，强烈的排尿欲望会降低步态速度。
4 级。
