Department of Neurology, Sørlandet Hospital Trust, Kristiansand, Norway.
Department of Infectious Disease Immunology, Norwegian Institute of Public Health, Oslo, Norway.
Ticks Tick Borne Dis. 2020 Jul;11(4):101410. doi: 10.1016/j.ttbdis.2020.101410. Epub 2020 Mar 8.
The tick Ixodes ricinus is widespread along the coastline of southern Norway, but data on human exposure to tick-borne microbes are scarce. We aimed to assess the seroprevalence of IgG antibodies to various tick-borne microbes in the general adult population living in a Norwegian municipality where ticks are abundant. Søgne is a coastline municipality in the southernmost part of Norway, and has a high density of ticks. All individuals aged 18-69 years with residential address in Søgne municipality (n = 7424) were invited to give a blood sample and answer a questionnaire. Blood samples from 3568 individuals were available for analysis. All samples were analyzed for IgG antibodies to Borrelia burgdorferi sensu lato (Bbsl), and around 1500 samples for IgG antibodies to other tick-borne microbes. Serum IgG antibodies to Bbsl were present in 22.0% (785/3568) of the tested samples, tick-borne encephalitis virus (TBEV) in 3.1% (45/1453), Anaplasma phagocytophilum in 11.0% (159/1452), Babesia microti in 2.1% (33/1537), Bartonella henselae/B. quintana in 0.1% (2/1451) and Rickettsia helvetica/R. conorii in 4.2% (60/1445). Serum IgG antibodies to A. phagocytophilum and R. helvetica/R. conorii were significantly more prevalent (p = 0.010 and p = 0.016, respectively) among individuals with serum IgG antibodies to Bbsl than among individuals without. In conclusion, our study showed a high exposure to Bbsl in the general adult population living in a coastline municipality in the southernmost part of Norway. The population is also exposed to A. phagocytophilum, R. helvetica/R. conorii, B. microti and TBEV, but very rarely B. henselae/B. quintana.
在挪威南部沿海地区广泛分布着蓖子硬蜱（Ixodes ricinus），但有关人类接触蜱传微生物的数据却很少。我们旨在评估生活在挪威一个蜱虫丰富的自治市的普通成年人群中，各种蜱传微生物 IgG 抗体的血清阳性率。Søgne 是挪威最南端的一个沿海自治市，蜱虫密度很高。所有居住在 Søgne 自治市的 18-69 岁的个人（n=7424）都被邀请提供血液样本并回答问卷。共有 3568 人的血液样本可供分析。所有样本均进行了 IgG 抗体对博尔纳病螺旋体（Bbsl）的分析，大约 1500 个样本进行了 IgG 抗体对其他蜱传微生物的分析。在检测的 3568 个样本中，22.0%（785/3568）的样本存在 Bbsl 血清 IgG 抗体，3.1%（45/1453）的样本存在 tick-borne encephalitis virus（TBEV），11.0%（159/1452）的样本存在嗜吞噬细胞无形体（Anaplasma phagocytophilum），2.1%（33/1537）的样本存在微小巴贝斯虫（Babesia microti），0.1%（2/1451）的样本存在汉塞巴尔通体/ quintana 亚种（Bartonella henselae/B. quintana），4.2%（60/1445）的样本存在立氏立克次体/康氏立克次体（Rickettsia helvetica/R. conorii）。与无 Bbsl 血清 IgG 抗体的个体相比，有 Bbsl 血清 IgG 抗体的个体中血清 IgG 抗体对嗜吞噬细胞无形体和立氏立克次体/康氏立克次体的阳性率显著更高（p=0.010 和 p=0.016）。总之，我们的研究表明，生活在挪威最南端沿海自治市的普通成年人群中，Bbsl 的暴露水平很高。该人群还暴露于嗜吞噬细胞无形体、立氏立克次体/康氏立克次体、微小巴贝斯虫和 TBEV，但非常罕见地暴露于汉塞巴尔通体/ quintana 亚种。
