Sloupenska Kristyna, Dolezilkova Jana, Koubkova Barbora, Hutyrova Beata, Racansky Mojmir, Horak Pavel, Golovchenko Maryna, Raska Milan, Rudenko Natalie, Krupka Michal
Department of Immunology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 779 00 Olomouc, Czech Republic.
Laboratory of Medical Parasitology and Zoology, Public Health Institute Ostrava, Partyzanske Namesti 7, 702 00 Ostrava, Czech Republic.
Microorganisms. 2021 Oct 25;9(11):2217. doi: 10.3390/microorganisms9112217.
The hypothesized importance of coinfections in the pathogenesis of post-treatment Lyme disease syndrome (PTLDS) leads to the use of combined, ongoing antimicrobial treatment in many cases despite the absence of symptoms typical of the presence of infection with specific pathogens. Serum samples from 103 patients with suspected post-treatment Lyme disease syndrome were tested for the presence of antibodies to the major tick-borne pathogens , /, and . Although the presence of anti- antibodies was detected in 12.6% of the samples and anti- antibodies in 9.7% of the samples, the presence of antibodies against both pathogens in the same samples or anti- antibodies in the selected group of patients could not be confirmed. However, we were able to detect autoantibodies, mostly antinuclear, in 11.6% of the patients studied. Our results are in good agreement with previously published studies showing the presence of a wide spectrum of autoantibodies in some patients with complicated forms of Lyme disease and post-treatment Lyme disease syndrome, but they do not reveal a significant influence of co-infections on the development of PTLDS in the studied group of patients.
尽管缺乏特定病原体感染的典型症状，但合并感染在治疗后莱姆病综合征（PTLDS）发病机制中的假设重要性，导致在许多情况下使用联合、持续的抗菌治疗。对103例疑似治疗后莱姆病综合征患者的血清样本进行检测，以确定是否存在针对主要蜱传病原体、、和的抗体。虽然在12.6%的样本中检测到抗抗体，在9.7%的样本中检测到抗抗体，但无法证实同一样本中同时存在针对两种病原体的抗体，或在选定患者组中检测到抗抗体。然而，我们在11.6%的研究患者中检测到自身抗体，主要是抗核抗体。我们的结果与先前发表的研究结果高度一致，这些研究表明，在一些患有复杂形式莱姆病和治疗后莱姆病综合征的患者中存在广泛的自身抗体，但它们并未揭示合并感染对所研究患者组中PTLDS发展的显著影响。
