Department of Biology, School of Biomedicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
Department of Biology, School of Sciences and Art Science, National University of Mongolia, Ulaanbaatar, Mongolia.
PLoS One. 2023 Aug 8;18(8):e0289274. doi: 10.1371/journal.pone.0289274. eCollection 2023.
Borrelia burgdorferi sensu lato and Rickettsia spp. are worldwide causes of tick-borne infections. We aimed to estimate the seroprevalence of immunoglobulin G (IgG) antibodies against different tick-borne diseases (TBDs) and determine risk factors among Mongolians from 2016 to 2020. Blood samples were obtained from voluntary participants with a history of suspected tick bite who visited our hospital, and IgG antibodies against Rickettsia and Borrelia were detected using enzyme-linked immunosorbent assay (ELISA). The IgG antibody seropositivity rate against Rickettsia was 21.8% (1032/4724), while 3.4% (162/4724) of participants tested positive for serum IgG antibodies against Borrelia by ELISA.Binary logistic regression analysis was performed to evaluate risk factors for tick-borne rickettsiosis (TBR) and tick-borne borreliosis (TBB) using IgG serum sample. Age, occupation, and residence were significantly associated with these diseases; however, sex did not show any significant association. Seroprevalence was significantly higher among herders (40.6%, 95% confidence interval [CI]: 35.5-45.8; odds ratio [OR] 0.61; P < 0.001) and students (32.8%, 95% CI: 30.2-35.4; OR 0.75; P < 0.001) than among individuals with other occupations. The 25-29 age group had a slightly higher seroprevalence (35.1%, 95% CI: 28.1-42.6; OR 0.61; P < 0.006) than those in other age groups. Province was a stronger predictor of TBR than occupation and age group. In univariate subgroup analysis by age group, occupation, and residence were significantly associated with TBR seroprevalence, whereas age and province were associated with TBB seroprevalence. Thus, risk factors for TBD include residence, occupation, and age group. This study was conducted using samples from all Mongolian provinces and the capital city, and the risk factors and prevalence of Rickettsia and Borreliaare highlighted.
伯氏疏螺旋体和立克次体属是引起蜱传感染的全球病原体。我们旨在评估 2016 年至 2020 年蒙古人感染不同蜱传疾病（TBD）的 IgG 抗体血清流行率，并确定其危险因素。从疑似蜱叮咬的患者中采集自愿参与者的血液样本，使用酶联免疫吸附试验（ELISA）检测立克次体和伯氏疏螺旋体的 IgG 抗体。ELISA 检测血清 IgG 抗体对伯氏疏螺旋体的阳性率为 3.4%（162/4724），对立克次体的阳性率为 21.8%（1032/4724）。采用二元逻辑回归分析评估 IgG 血清样本中蜱传立克次体病（TBR）和蜱传伯氏疏螺旋体病（TBB）的危险因素。年龄、职业和居住地与这些疾病显著相关；然而，性别没有显示出任何显著关联。牧民（40.6%，95%置信区间[CI]：35.5-45.8；优势比[OR] 0.61；P<0.001）和学生（32.8%，95%CI：30.2-35.4；OR 0.75；P<0.001）的血清流行率明显高于其他职业人群。25-29 岁年龄组的血清流行率略高（35.1%，95%CI：28.1-42.6；OR 0.61；P<0.006），高于其他年龄组。省份对立克次体病的预测作用强于职业和年龄组。按年龄组、职业和居住地进行的单变量亚组分析显示，TBR 血清流行率与年龄组、职业和居住地显著相关，而 TBB 血清流行率与年龄和省份显著相关。因此，TBD 的危险因素包括居住地、职业和年龄组。本研究在蒙古所有省份和首都的样本上进行，强调了立克次体和伯氏疏螺旋体的危险因素和流行率。
