Luo Wenhao, Yang Gang, Luo Wentao, Cao Zhe, Liu Yueze, Qiu Jiangdong, Chen Guangyu, You Lei, Zhao Fangyu, Zheng Lianfang, Zhang Taiping
1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing Street, Beijing, 100730 China.
2Department of Mechanical Engineering, Tsinghua University, Beijing, 100084 China.
Cancer Cell Int. 2020 Mar 4;20:66. doi: 10.1186/s12935-020-1147-9. eCollection 2020.
Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer.
胰腺癌是一种侵袭性恶性肿瘤，死亡率极高。与无转移的胰腺癌患者相比，发生转移的胰腺癌患者的生活质量和生存率较差。迄今为止，尚未为转移性胰腺癌患者建立有效的治疗策略。因此，基于消除转移性胰腺癌的适当治疗方法对于改善患者预后至关重要。肿瘤靶向疫苗在最近的研究中得到了广泛讨论，并通过防止肿瘤细胞从免疫监视中逃逸和激活免疫系统以消除癌细胞，在胰腺癌治疗中取得了重要突破。肿瘤靶向疫苗可刺激激活T细胞，但要产生有效的免疫反应，既需要免疫检查点抑制剂，也需要阳性共刺激分子。在这篇综述中，我们讨论了可靶向胰腺癌的潜在肿瘤靶向疫苗，阐述了可能合适的疫苗治疗组合，并评估了当前转移性胰腺癌治疗的潜在益处和障碍。
