Gebrie Alemu, Tesfaye Bekele, Gebru Tensae, Adane Fentahun, Abie Worku, Sisay Mekonnen
1Department of Biomedical Science, School of Medicine, Debre Markos University, P.O. Box 269, Debre Markos, Ethiopia.
2Department of Nursing, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Diabetol Metab Syndr. 2020 Mar 4;12:20. doi: 10.1186/s13098-020-00527-1. eCollection 2020.
The use of highly active anti- retroviral therapy (HAART) as well as human immunodeficiency virus (HIV) per se have been shown to be related with diabetes among patients living with HIV. There is limited evidence on the prevalence of diabetes among HIV-infected patients in developing countries like Ethiopia. Therefore, the aim of this study is to determine the prevalence of diabetes among patients living with HIV/AIDS at referral hospitals of Northwest Ethiopia.
a hospital based cross-sectional study was conducted at referral hospitals of Northwest Ethiopia between February 2019 and April 2019. Using WHO stepwise approach, sociodemographic, behavioral and clinical data were collected from 407 included adult patients. Simple random sampling methods was used to select the study participants. Lipid profiles, fasting blood sugar as well as anthropometric indicators were also measured. SPSS version 25 was used for analysis of data; bivariate and multivariate binary logistic regression analysis was performed.
From a total of 415 patients living with HIV deemed eligible for inclusion, 407 with complete data were included in the final analysis giving a response rate of 98%. From 407 study subjects included in the analysis, 161 (39.6%) were men. The prevalence of diabetes mellitus was found to be 8.8% (95% CI 6.05, 11.55). Multivariate logistic regression analysis revealed that age [AOR (95% CI) 1.04 (1.001,1.084), p < 0.05], educational status [AOR (95% CI) 6.27 (1.72, 22.85), p < 0.05, diploma; AOR (95% CI) 9.64 (2.57, 36.12), p < 0.05, degree and above], triglyceride level [AOR (95% CI) 1.007 (1.003, 1.010), p < 0.01] have shown statistically significant association with odds of diabetes mellitus.
The prevalence of diabetes was notably high in patients living with HIV/AIDS. Factors such as increased age, educational status and higher level of serum triglyceride were found to contribute to this high prevalence of diabetes.
高效抗逆转录病毒疗法（HAART）的使用以及人类免疫缺陷病毒（HIV）本身已被证明与HIV感染者中的糖尿病有关。在埃塞俄比亚等发展中国家，关于HIV感染患者中糖尿病患病率的证据有限。因此，本研究的目的是确定埃塞俄比亚西北部转诊医院中HIV/AIDS患者的糖尿病患病率。
2019年2月至2019年4月在埃塞俄比亚西北部的转诊医院进行了一项基于医院的横断面研究。采用世界卫生组织的逐步方法，从407名纳入研究的成年患者中收集社会人口统计学、行为和临床数据。使用简单随机抽样方法选择研究参与者。还测量了血脂谱、空腹血糖以及人体测量指标。使用SPSS 25版进行数据分析；进行了双变量和多变量二元逻辑回归分析。
在总共415名被认为符合纳入条件的HIV患者中，407名有完整数据的患者被纳入最终分析，应答率为98%。在分析纳入的407名研究对象中，161名（39.6%）为男性。糖尿病患病率为8.8%（95%CI 6.05，11.55）。多变量逻辑回归分析显示，年龄[AOR（95%CI）1.04（1.001，1.084），p＜0.05]、教育程度[AOR（95%CI）6.27（1.72，22.85），p＜0.05，文凭；AOR（95%CI）9.64（2.57，36.12），p＜0.05，学位及以上]、甘油三酯水平[AOR（95%CI）1.007（1.003，1.010），p＜0.01]与糖尿病患病几率有统计学显著关联。
HIV/AIDS患者中糖尿病患病率显著较高。年龄增加、教育程度和血清甘油三酯水平较高等因素被发现导致了糖尿病的高患病率。
