Patricia and John Rosenwald Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY.
J Exp Med. 2020 Apr 6;217(4). doi: 10.1084/jem.20191865.
Plasminogen and its active form, plasmin, have diverse functions related to the inflammatory response in mammals. Due to these roles in inflammation, plasminogen has been implicated in the progression of a wide range of diseases with an inflammatory component. In this review, we discuss the functions of plasminogen in inflammatory regulation and how this system plays a role in the pathogenesis of diseases spanning organ systems throughout the body.
纤溶酶原及其活性形式纤溶酶在哺乳动物的炎症反应中具有多种功能。由于在炎症中的这些作用，纤溶酶原与具有炎症成分的广泛疾病的进展有关。在这篇综述中，我们讨论了纤溶酶原在炎症调节中的作用，以及该系统如何在贯穿全身各个器官系统的疾病发病机制中发挥作用。
