Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga, Japan.
Faculty of Engineering Sciences, Kyushu University, Kasuga, Japan.
Indoor Air. 2020 Sep;30(5):1018-1038. doi: 10.1111/ina.12666. Epub 2020 Apr 6.
Electronic (e)-cigarette smoking is considered to be less harmful than traditional tobacco smoking because of the lack of a combustion process. However, e-cigarettes have the potential to release harmful chemicals depending on the constituents of the vapor. To date, there has been significant evidence on the adverse health effects of e-cigarette usage. However, what is less known are the impacts of the chemicals contained in exhaled air from an e-cigarette smoker on indoor air quality, the second-hand passive smoking of residents, and the toxicity of the exhaled air. In this study, we develop a comprehensive numerical model and computer-simulated person to investigate the potential effects of e-cigarette smoking on local tissue dosimetry and the deterioration of indoor air quality. We also conducted demonstrative numerical analyses for first-hand and second-hand e-cigarette smoking in an indoor environment. To investigate local tissue dosimetry, we used newly developed physiologically based pharmacokinetic/toxicokinetic models that reproduce inhalation exposure by way of the respiratory tract and dermal exposure through the human skin surface. These models were integrated into the computer-simulated person. Our numerical simulation results quantitatively demonstrated the potential impacts of e-cigarette smoking in enclosed spaces on indoor air quality.
电子（e）香烟由于缺乏燃烧过程，被认为比传统香烟危害小。然而，电子香烟有可能根据蒸汽的成分释放有害化学物质。迄今为止，已经有大量证据表明电子烟的使用对健康有不良影响。然而，人们对电子烟吸烟者呼出的空气中所含化学物质对室内空气质量、居民的二手被动吸烟以及呼出空气的毒性的影响知之甚少。在这项研究中，我们开发了一个综合的数值模型和计算机模拟人，以研究电子烟吸烟对局部组织剂量和室内空气质量恶化的潜在影响。我们还对室内环境中的一手和二手电子烟吸烟进行了示范性数值分析。为了研究局部组织剂量，我们使用了新开发的基于生理学的药代动力学/毒代动力学模型，通过呼吸道模拟吸入暴露，并通过人体皮肤表面模拟皮肤接触暴露。这些模型被整合到计算机模拟人。我们的数值模拟结果定量地证明了在封闭空间中电子烟吸烟对室内空气质量的潜在影响。
