Farhangi Mahdieh Abbasalizad
Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
BMC Res Notes. 2020 Mar 11;13(1):145. doi: 10.1186/s13104-020-04993-8.
Gene- nutrient interaction might possibly be involved in the pathogenesis of metabolic syndrome and its components. In the current report, the association between antioxidant potential of the diet with 6P21 rs2010963 gene polymorphism in patients with metabolic syndrome has been evaluated. Two hundred fifty-four patients with metabolic syndrome were enrolled. Total dietary antioxidant capacity (TAC) has been estimated and anthropometric assessments were assessed. Biochemical assays including serum glucose, matrix metalloproteinase-3, liver enzymes and lipid profiles were also assessed. Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method was used for determination of 6P21 rs2010963 polymorphism.
Dietary vitamin E score was significantly higher in GC genotype compared with other genotypes (P = 0.035). Patients in CC genotype of 6P21 rs2010963 had significantly higher body mass index (BMI), fasting blood sugar and liver enzymes (P < 0.05). Being in the higher dietary TAC scores was also associated with lower liver enzymes. The interaction between 6P21 rs2010963 and dietary TAC significantly affected BMI, FBS and diastolic blood pressure (P < 0.05). According to our findings the CC genotype of 6P21 rs2010963 could be considered as the possible risk factor for obesity and metabolic disorders among patients with metabolic syndrome.
基因-营养素相互作用可能参与代谢综合征及其组分的发病机制。在本报告中，已评估了代谢综合征患者饮食的抗氧化潜力与6P21 rs2010963基因多态性之间的关联。纳入了254例代谢综合征患者。估计了总膳食抗氧化能力（TAC）并进行了人体测量评估。还评估了包括血清葡萄糖、基质金属蛋白酶-3、肝酶和血脂谱在内的生化检测。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法测定6P21 rs2010963多态性。
与其他基因型相比，GC基因型的膳食维生素E评分显著更高（P = 0.035）。6P21 rs2010963的CC基因型患者的体重指数（BMI）、空腹血糖和肝酶显著更高（P < 0.05）。较高的膳食TAC评分也与较低的肝酶相关。6P21 rs2010963与膳食TAC之间的相互作用显著影响BMI、空腹血糖和舒张压（P < 0.05）。根据我们的研究结果，6P21 rs2010963的CC基因型可被视为代谢综合征患者肥胖和代谢紊乱的可能危险因素。
