Nutrition and Endocrine Research Centre, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sci Rep. 2017 May 10;7(1):1649. doi: 10.1038/s41598-017-01762-9.
There are conflicting data on the impact of zinc transporter 8 (ZNT8) gene variations on the metabolic syndrome (MetS). Hence, the effects of the interaction between rs13266634 and dietary factors on the risk of MetS were investigated in this study. Subjects of this nested case-control study were selected from the participants in Tehran Lipid and Glucose Study. Each of the cases (n = 817) was individually matched with a control. Dietary patterns were determined using factor analysis. The ZNT8 rs13266634 were genotyped by the Tetra-refractory mutation system-polymerase chain reaction analysis. Two dietary patterns were extracted. There were no significant interactions between the ZNT8 SNP and the dietary patterns on the risk of MetS or its components. An interaction was observed between rs13266634 and the omega-3 fatty acid intakes on the risk of MetS in subjects with the CC genotype (P interaction < 0.01). Zinc modified the association of the ZNT8 variant with high fasting blood sugar (P interaction = 0.05) in CC genotype carriers. An interaction was also observed between rs13266634 and salty snacks at the risk of abdominal obesity (P interaction < 0.05). Our findings suggest an interaction between omega-3 fatty acids, zinc, salty snacks and rs13266634, which may affect the risk of MetS or its components.
关于锌转运蛋白 8 (ZNT8) 基因变异对代谢综合征 (MetS) 的影响存在相互矛盾的数据。因此，本研究调查了 rs13266634 与饮食因素之间的相互作用对 MetS 风险的影响。本巢式病例对照研究的受试者选自德黑兰血脂和血糖研究的参与者。每个病例（n=817）均与一个对照个体匹配。使用因子分析确定饮食模式。ZNT8 rs13266634 通过四管难治性突变系统聚合酶链反应分析进行基因分型。提取了两种饮食模式。ZNT8 SNP 与饮食模式之间在 MetS 或其成分的风险上无显著相互作用。在 CC 基因型受试者中，rs13266634 与 ω-3 脂肪酸摄入量之间观察到相互作用与 MetS 风险相关（P 交互<0.01）。锌修饰了 ZNT8 变体与空腹血糖升高之间的关联（P 交互=0.05）在 CC 基因型携带者中。在腹型肥胖的风险中，还观察到 rs13266634 与咸点之间的相互作用（P 交互<0.05）。我们的研究结果表明，ω-3 脂肪酸、锌、咸点和 rs13266634 之间存在相互作用，可能会影响 MetS 或其成分的风险。
