Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
Development. 2020 Mar 11;147(5):dev179325. doi: 10.1242/dev.179325.
Skeletal stem cells (SSCs) generate the progenitors needed for growth, maintenance and repair of the skeleton. Historically, SSCs have been defined as bone marrow-derived cells with inconsistent characteristics. However, recent tracking experiments have revealed the presence of SSCs not only within the bone marrow but also within the periosteum and growth plate reserve zone. These studies show that SSCs are highly heterogeneous with regard to lineage potential. It has also been revealed that, during digit tip regeneration and in some non-mammalian vertebrates, the dedifferentiation of osteoblasts may contribute to skeletal regeneration. Here, we examine how these research findings have furthered our understanding of the diversity and plasticity of SSCs that mediate skeletal maintenance and repair.
成骨细胞（SSCs）生成骨骼生长、维持和修复所需的祖细胞。从历史上看，SSCs 被定义为骨髓来源的细胞，具有不一致的特征。然而，最近的追踪实验表明，SSC 不仅存在于骨髓中，而且存在于骨膜和生长板储备区。这些研究表明，SSC 具有高度的谱系潜能异质性。此外，研究还揭示，在指尖再生和某些非哺乳动物脊椎动物中，成骨细胞的去分化可能有助于骨骼再生。在这里，我们研究了这些研究结果如何进一步加深我们对介导骨骼维持和修复的 SSCs 的多样性和可塑性的理解。
