Kyriazoglou Anastasios, Koutsoukos Konstantinos, Zagouri Flora, Liontos Michalis, Dimitriadis Efthimios, Tiniakos Dina, Dimopoulos Meletios Athanasios
Department of Clinical Therapeutics, General Hospital Alexandra, Athens, Greece.
Department of Genetics, Agios Savvas Hospital, Athens, Greece.
Ther Clin Risk Manag. 2020 Feb 27;16:141-146. doi: 10.2147/TCRM.S220804. eCollection 2020.
Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor with indolent course. Liver transplantation for local disease is the treatment of choice. In the metastatic setting there is no consensus regarding the appropriate systemic treatment. We present two cases of metastatic hepatic epithelioid hemangioendothelioma (hEHE) treated with the combination of Doxorubicin and Olaratumab. Both patients showed Stable Disease (SD) as a response, after the completion of six cycles of this combination therapy.
上皮样血管内皮瘤（EHE）是一种病程缓慢的罕见血管恶性肿瘤。对于局部病变，肝移植是首选治疗方法。在转移性情况下，关于合适的全身治疗尚无共识。我们报告了两例接受阿霉素和奥拉单抗联合治疗的转移性肝上皮样血管内皮瘤（hEHE）病例。在完成六个周期的联合治疗后，两名患者均表现出病情稳定（SD）的反应。
