维生素C对急性运动后氧化应激、炎症、肌肉酸痛和力量的影响：随机临床试验的荟萃分析
Effects of vitamin C on oxidative stress, inflammation, muscle soreness, and strength following acute exercise: meta-analyses of randomized clinical trials.
作者信息
Righi Natiele Camponogara, Schuch Felipe Barreto, De Nardi Angélica Trevisan, Pippi Caroline Montagner, de Almeida Righi Geovana, Puntel Gustavo Orione, da Silva Antonio Marcos Vargas, Signori Luis Ulisses
机构信息
Department of Physiotherapy and Rehabilitation, Postgraduate Program in Functional Rehabilitation, Federal University of Santa Maria-UFSM, Av. Roraima nº 1000, Cidade Universitária, Bairro Camobi, Santa Maria, RS, 97105-900, Brazil.
Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, RS, Brazil.
出版信息
Eur J Nutr. 2020 Oct;59(7):2827-2839. doi: 10.1007/s00394-020-02215-2. Epub 2020 Mar 11.
BACKGROUND
Vitamin C (ascorbic acid) seems to attenuate the overproduction of reactive species during and after exercises. Yet, no meta-analysis has summarized the magnitude of this effect. The objective of this study was to systematically review the effects of vitamin C supplementation on oxidative stress, inflammatory markers, damage, soreness, and the musculoskeletal functionality after a single bout of exercise.
METHODS
Major electronic databases were searched, from inception to September 2019, for placebo-controlled randomized clinical trials (RCTs) that evaluated the effects of vitamin C supplementation on oxidative stress parameters, inflammation markers, muscle damage, muscle soreness, and muscle functionality after a single bout of exercise in healthy volunteers. Random-effects modelling was used to compare mean changes from pre- to postexercise in participants that were supplemented with vitamin C versus placebo. Data were reported as standard mean difference (SMD) and 95% confidence interval (CI).
RESULTS
A total of 18 RCTs, accounting for 313 participants (62% males, median age = 24 years) were included. Vitamin C supplementation reduced lipid peroxidation immediately (SMD = - 0.488; 95% CI = - 0.888 to - 0.088), 1 h (SMD = - 0.521; 95% CI = - 0.911 to - 0.131) and between 1 and 2 h (SMD = - 0.449; 95% CI = - 0.772 to - 0.126) following exercise. Exercise induced interleukin-6 (IL-6) response was attenuated 2 h (SMD = - 0.764; 95% CI = - 1.279 to - 0.248) and between 1 and 2 h (SMD = - 0.447; 95% CI = - 0.828 to - 0.065) after exercise. No effects of vitamin C supplementation were found on creatine kinase (CK), C-reactive protein (CRP), cortisol levels, muscle soreness, and muscle strength.
CONCLUSION
Vitamin C supplementation attenuates the oxidative stress (lipid peroxidation) and inflammatory response (IL-6) to a single bout of exercise.
REGISTRATION
PROSPERO (CRD42018094222).
背景
维生素C（抗坏血酸）似乎能减轻运动期间及运动后的活性物质过量产生。然而，尚无荟萃分析总结这种作用的程度。本研究的目的是系统评价补充维生素C对单次运动后氧化应激、炎症标志物、损伤、酸痛及肌肉骨骼功能的影响。
方法
检索主要电子数据库，从建库至2019年9月，查找安慰剂对照的随机临床试验（RCT），这些试验评估了补充维生素C对健康志愿者单次运动后氧化应激参数、炎症标志物、肌肉损伤、肌肉酸痛和肌肉功能的影响。采用随机效应模型比较补充维生素C组与安慰剂组参与者运动前至运动后的平均变化。数据以标准平均差（SMD）和95%置信区间（CI）报告。
结果
共纳入18项RCT，涉及313名参与者（62%为男性，年龄中位数=24岁）。补充维生素C可在运动后即刻（SMD=-0.488；95%CI=-0.888至-0.088）、1小时（SMD=-0.521；95%CI=-0.911至-0.131）以及1至2小时（SMD=-0.449；95%CI=-0.772至-0.126）降低脂质过氧化。运动诱导的白细胞介素-6（IL-6）反应在运动后2小时（SMD=-0.764；95%CI=-1.279至-0.248）以及1至2小时（SMD=-0.447；95%CI=-0.
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