Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
Biosci Rep. 2020 Apr 30;40(4). doi: 10.1042/BSR20200257.
Mitochondria are intracellular organelles with two distinct membranes, known as an outer mitochondrial membrane and inner cell membrane. Originally, mitochondria have been derived from bacteria. The main function of mitochondria is the production of ATP. However, this important organelle indirectly protects cells by consuming oxygen in the route of energy generation. It has been found that mitochondria are actively involved in the induction of the intrinsic pathways of apoptosis. So, there have been efforts to sustain mitochondrial homeostasis and inhibit its dysfunction. Notably, due to the potential role of mitochondria in the stimulation of apoptosis, this organelle is a promising target in cancer therapy. Resveratrol is a non-flavonoid polyphenol that exhibits significant pharmacological effects such as antioxidant, anti-diabetic, anti-inflammatory and anti-tumor. The anti-tumor activity of resveratrol may be a consequence of its effect on mitochondria. Multiple studies have investigated the relationship between resveratrol and mitochondria, and it has been demonstrated that resveratrol is able to significantly enhance the concentration of reactive oxygen species, leading to the mitochondrial dysfunction and consequently, apoptosis induction. A number of signaling pathways such as sirtuin and NF-κB may contribute to the mitochondrial-mediated apoptosis by resveratrol. Besides, resveratrol shifts cellular metabolism from glycolysis into mitochondrial respiration to induce cellular death in cancer cells. In the present review, we discuss the possible interactions between resveratrol and mitochondria, and its potential application in cancer therapy.
线粒体是具有双层膜的细胞内细胞器，分别称为外线粒体膜和内膜。最初，线粒体来源于细菌。线粒体的主要功能是产生 ATP。然而，这个重要的细胞器通过在能量产生过程中消耗氧气来间接保护细胞。已经发现线粒体积极参与细胞凋亡的内在途径的诱导。因此，人们一直致力于维持线粒体的动态平衡并抑制其功能障碍。值得注意的是，由于线粒体在细胞凋亡刺激中的潜在作用，该细胞器是癌症治疗中有前途的靶点。白藜芦醇是一种非黄酮多酚，具有显著的药理作用，如抗氧化、抗糖尿病、抗炎和抗肿瘤。白藜芦醇的抗肿瘤活性可能是其对线粒体作用的结果。多项研究探讨了白藜芦醇与线粒体之间的关系，结果表明白藜芦醇能够显著提高活性氧的浓度，导致线粒体功能障碍，进而诱导细胞凋亡。白藜芦醇可能通过 SIRT1 和 NF-κB 等多种信号通路诱导线粒体介导的细胞凋亡。此外，白藜芦醇将细胞代谢从糖酵解转变为线粒体呼吸，从而诱导癌细胞死亡。在本综述中，我们讨论了白藜芦醇与线粒体之间可能存在的相互作用及其在癌症治疗中的潜在应用。
