First Clinical Medical School, Heilongjiang University of Chinese Medicine, Harbin, 150040, China.
Clinical Medical School, Chengdu University of Traditional Chinese Medicine, Chengdu, 610036, China.
Chin J Integr Med. 2024 Oct;30(10):949-960. doi: 10.1007/s11655-024-3657-0. Epub 2024 Feb 8.
Acute myocardial infarction (AMI), characterized by high incidence and mortality rates, poses a significant public health threat. Reperfusion therapy, though the preferred treatment for AMI, often exacerbates cardiac damage, leading to myocardial ischemia/reperfusion injury (MI/RI). Consequently, the development of strategies to reduce MI/RI is an urgent priority in cardiovascular therapy. Chinese medicine, recognized for its multi-component, multi-pathway, and multi-target capabilities, provides a novel approach for alleviating MI/RI. A key area of interest is the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. This pathway is instrumental in regulating inflammatory responses, oxidative stress, apoptosis, endoplasmic reticulum stress, and ferroptosis in MI/RI. This paper presents a comprehensive overview of the Nrf2/HO-1 signaling pathway's structure and its influence on MI/RI. Additionally, it reviews the latest research on leveraging Chinese medicine to modulate the Nrf2/HO-1 pathway in MI/RI treatment.
急性心肌梗死（AMI）具有发病率和死亡率高的特点，对公众健康构成重大威胁。再灌注治疗虽然是 AMI 的首选治疗方法，但常导致心肌损伤加重，引发心肌缺血/再灌注损伤（MI/RI）。因此，开发减轻 MI/RI 的策略是心血管治疗的当务之急。中药以其多成分、多途径、多靶点的特点，为缓解 MI/RI 提供了新的思路。其中一个关注的重点是核因子 E2 相关因子 2（Nrf2）/血红素加氧酶-1（HO-1）通路。该通路在调节 MI/RI 中的炎症反应、氧化应激、细胞凋亡、内质网应激和铁死亡方面发挥着重要作用。本文全面概述了 Nrf2/HO-1 信号通路的结构及其对 MI/RI 的影响。此外，还综述了利用中药调节 Nrf2/HO-1 通路治疗 MI/RI 的最新研究进展。
