Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008 Pamplona, Spain.
Department of Clinical Oncology, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
Nutrients. 2020 Mar 10;12(3):731. doi: 10.3390/nu12030731.
Alcohol intake is associated with the risk of breast cancer. Different patterns of alcohol-drinking may have different effects on breast cancer even when keeping constant the total amount of alcohol consumed. We aimed to assess the association between binge drinking and breast cancer risk. The SUN Project is a Spanish dynamic prospective cohort of university graduates initiated in 1999. In the 556-item lifestyle baseline questionnaire a validated food-frequency questionnaire was embedded. Participants completed biennial follow-up questionnaires. Cox regression models were used to estimate the hazard ratio (HR) for breast cancer associated with the exposure to binge drinking. A stratified analysis was performed according to menopausal status. We included 9577 women (mean age = 34 years, SD = 10 years), with a median follow-up of 11.8 years. Among 104,932 women-years of follow-up, we confirmed 88 incident cases of breast cancer. Women in the binge drinking group showed a higher risk of breast cancer (HR = 1.76; 95% CI: 1.03-2.99) compared to women in the non-binge drinking category. In the stratified analysis, a 2-fold higher risk for premenopausal breast cancer was associated with binge drinking habit (HR = 2.06; 95% CI: 1.11-3.82). This study adds new evidence on the association of binge drinking with breast cancer risk.
饮酒与乳腺癌风险相关。即使保持饮酒总量不变，不同的饮酒模式可能对乳腺癌有不同的影响。我们旨在评估狂饮与乳腺癌风险之间的关联。SUN 项目是一项始于 1999 年的西班牙动态前瞻性大学毕业生队列研究。在包含 556 个项目的生活方式基线问卷中嵌入了一份经过验证的食物频率问卷。参与者每两年完成一次随访问卷。使用 Cox 回归模型估计与狂饮暴露相关的乳腺癌风险的风险比（HR）。根据绝经状态进行分层分析。我们纳入了 9577 名女性（平均年龄=34 岁，标准差=10 岁），中位随访时间为 11.8 年。在 104932 名女性随访年中，我们确认了 88 例乳腺癌病例。与非狂饮组相比，狂饮组的女性乳腺癌风险更高（HR=1.76；95%CI：1.03-2.99）。在分层分析中，与狂饮习惯相关的绝经前乳腺癌风险增加了 2 倍（HR=2.06；95%CI：1.11-3.82）。这项研究为狂饮与乳腺癌风险之间的关联提供了新的证据。
