Alrobaiq Bandar M, Alharbi Rashed S, Alhoshan Faisal S, Alnasyan Mohammed A, Alahideb Abdulrahman, Omair Aamir
College of Medicine, King Saud Bin Abdulaziz University for Health Sciences College of Medicine, Riyadh, SAU.
Medical Education, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Cureus. 2023 Feb 22;15(2):e35294. doi: 10.7759/cureus.35294. eCollection 2023 Feb.
Background There is limited evidence that evaluates the association between hypertension and ovarian cancer. The study aims to investigate the association between ovarian cancer and hypertension, the difference in lipid profile, and the association between body mass index (BMI) and ovarian cancer. Methods We conducted a case-control study at King Abdelaziz Medical City (KAMC), oncology department. All Saudi female patients who were diagnosed with primary ovarian cancer admitted to the oncology department at KAMC from 2016 to 2019 were selected. The data were collected from medical records of patients of the KAMC by chart review using The Ministry of National Guard Health Affairs BESTCare database. Results A total of 137 Saudi female patients diagnosed with ovarian cancer attending to gynecology and oncology center in KAMC from 2016 to 2019 were included in this study. The mean age of participants was 57 in cases and 56 in controls with a mean BMI of 29.64 in cases and 31 in controls. There were 63 obese cases, therefore, the proportion of obesity was 46%. Approximately one-third of cases were overweight (28%) while one-fourth (26%) of them were underweight or normal weight. Roughly two-thirds of cases were hypertensive with an overall proportion of 66 % (95% confidence interval (CI) 58-74) while one-third of controls were hypertensive with an overall proportion of 32%. Cases were having significantly higher triglycerides (p=0.03) and lower high-density lipoprotein (HDL) (p=0.001) than controls. The significant variables were analyzed using logistic regression. It was found that hypertensive subjects were 10.06 times more likely (95% CI: 4.88-20.71) to be associated with the cases as compared to controls (p<0.001). Also, an increase in BMI was significantly associated with being a case with OR = 1.07 (95% CI: 1.02-1.12; p=0.004). Conclusion In conclusion, hypertension, elevated BMI, higher triglycerides, and lower HDL were significantly associated with ovarian cancer.
评估高血压与卵巢癌之间关联的证据有限。本研究旨在调查卵巢癌与高血压之间的关联、血脂谱差异以及体重指数（BMI）与卵巢癌之间的关联。
我们在阿卜杜勒阿齐兹国王医疗城（KAMC）肿瘤科开展了一项病例对照研究。选取了2016年至2019年期间在KAMC肿瘤科确诊为原发性卵巢癌的所有沙特女性患者。通过使用国民卫队卫生事务部BESTCare数据库进行图表审查，从KAMC患者的病历中收集数据。
本研究纳入了2016年至2019年期间在KAMC妇科和肿瘤科就诊的137例确诊为卵巢癌的沙特女性患者。病例组参与者的平均年龄为57岁，对照组为56岁，病例组的平均BMI为29.64，对照组为31。有63例肥胖病例，因此肥胖比例为46%。约三分之一的病例超重（28%），而四分之一（26%）的病例体重过轻或正常体重。大约三分之二的病例患有高血压，总体比例为66%（95%置信区间（CI）58 - 74），而三分之一的对照组患有高血压，总体比例为32%。病例组的甘油三酯显著高于对照组（p = 0.03），高密度脂蛋白（HDL）显著低于对照组（p = 0.001）。使用逻辑回归分析显著变量。发现高血压患者与病例组相关的可能性是对照组的10.06倍（95% CI：4.88 - 20.71）（p < 0.001）。此外，BMI的增加与病例组显著相关，OR = 1.07（95% CI：1.02 - 1.12；p = 0.004）。
总之，高血压、BMI升高、甘油三酯升高和HDL降低与卵巢癌显著相关。
