牙周炎与炎症性肠病：一项荟萃分析。
Periodontitis and inflammatory bowel disease: a meta-analysis.
机构信息
Department of Stomatology, The Sixth Affiliated Hospital, Sun Yat-sen University, No.26 Yuancun Erheng Road, Tianhe District, 510655, Guangzhou, Guangdong, People's Republic of China.
Department of Stomatology, Sun Yat-Sen Memorial Hospital, Sun Yat-sen University, No.107 West Yanjiang Road, Yuexiu District, 510120, Guangzhou, Guangdong, People's Republic of China.
出版信息
BMC Oral Health. 2020 Mar 12;20(1):67. doi: 10.1186/s12903-020-1053-5.
BACKGROUND
Periodontitis was reported to be associated with inflammatory bowel disease (IBD). However, the association between them has not been firmly established in the existing literature. Therefore, this meta-analysis was conducted to evaluate the relationship between periodontitis and IBD.
METHODS
Electronic databases were searched for publications up to August 1, 2019 to include all eligible studies. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated to determine the association between periodontal disease and IBD using a random or fixed effects model according to heterogeneity.
RESULTS
Six eligible studies involving 599 IBD patients and 448 controls were included. The pooled OR between periodontitis and IBD was 3.17 (95% CI: 2.09-4.8) with no heterogeneity observed (I = 0.00%). The pooled ORs were 3.64 (95% CI: 2.33-5.67) and 5.37 (95% CI: 3.30-8.74) for the associations between periodontitis and the two sub-categories of IBD, Crohn' s disease and ulcerative colitis, respectively.
CONCLUSIONS
The results demonstrated that periodontitis was significantly associated with IBD. However, the mechanisms underlying periodontitis and IBD development are undetermined. Further studies are needed to elucidate this relationship.
背景
牙周炎与炎症性肠病（IBD）有关。然而，它们之间的关联在现有文献中尚未得到明确证实。因此，进行了这项荟萃分析，以评估牙周炎和 IBD 之间的关系。
方法
截至 2019 年 8 月 1 日，通过电子数据库搜索了所有符合条件的研究。使用随机或固定效应模型根据异质性估计汇总优势比（OR）和 95%置信区间（95%CI），以确定牙周病与 IBD 之间的关联。
结果
纳入了 6 项研究，共涉及 599 例 IBD 患者和 448 例对照。牙周炎与 IBD 之间的合并 OR 为 3.17（95%CI：2.09-4.8），未见异质性（I=0.00%）。牙周炎与 IBD 的两个亚类（克罗恩病和溃疡性结肠炎）的合并 OR 分别为 3.64（95%CI：2.33-5.67）和 5.37（95%CI：3.30-8.74）。
结论
结果表明牙周炎与 IBD 显著相关。然而，牙周炎和 IBD 发展的机制尚不确定。需要进一步的研究来阐明这种关系。
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