Widjaja Sry Suryani, Syahputra Muhammad O K, Ginting Almaycano
Biochemistry Department, Medical Faculty, Universitas of Sumatera Utara, Medan, Indonesia.
Clinical Pathology Department, Medical Faculty, Universitas of Sumatera Utara, Medan, Indonesia.
Open Access Maced J Med Sci. 2019 Dec 10;7(23):4066-4068. doi: 10.3889/oamjms.2019.860. eCollection 2019 Dec 15.
Diabetes and malignancy are two chronic diseases that have a major impact on the healthy population in developing countries, both contribute to the increase of morbidity and mortality of the patients. Diabetes presented with hyperglycemia due to insufficiency or resistance of insulin has been associated with an increased risk of thrombosis. Malignancy or cancer is number two killer in the developing countries after infectious diseases, one of the most common cause of death in cancer despite the disease itself is thrombosis, which occurred frequently as cancer cause changes in tumor biology, abnormal vascularisation, endothelial dysfunction, activation of coagulation and inflammation. Poor glucose control reflects by HbA1C has a significant correlation with a hypercoagulable state.
This study was to evaluate the relation between hypercoagulable state and glycemic control in diabetic patients with malignancy.
This is a case control study, eighty samples of diabetes (40 samples were diabetes with malignancy) were collected from private hospitals and clinics. HbA1c, blood glucose level and Ddimer were measured.
The forty five percent of the blood glucose level of the samples was not well controlled. Sixty five percent of the samples in this group were norm weight, overweight 20% and obese 10%. The Ddimer levels were elevated in both groups and there was a significant correlation between HbA1C and Ddimer (p-0.046), blood glucose and age (p = 0.017).
Chronic hyperglycemia will increase the risk of hypercoagulable state, that will also increase the morbidity and mortality rate in diabetes with malignancy patients.
糖尿病和恶性肿瘤是对发展中国家健康人群有重大影响的两种慢性疾病，二者均导致患者发病率和死亡率上升。因胰岛素分泌不足或抵抗导致血糖升高的糖尿病与血栓形成风险增加有关。恶性肿瘤是发展中国家仅次于传染病的第二大杀手，尽管癌症本身最常见的死因之一是血栓形成，这是由于癌症导致肿瘤生物学改变、血管异常、内皮功能障碍、凝血和炎症激活。糖化血红蛋白（HbA1C）所反映的血糖控制不佳与高凝状态显著相关。
本研究旨在评估合并恶性肿瘤的糖尿病患者高凝状态与血糖控制之间的关系。
这是一项病例对照研究，从私立医院和诊所收集了80例糖尿病样本（40例为合并恶性肿瘤的糖尿病患者）。检测了糖化血红蛋白、血糖水平和D - 二聚体。
样本中45%的血糖水平控制不佳。该组中65%的样本体重正常，超重20%，肥胖10%。两组的D - 二聚体水平均升高，糖化血红蛋白与D - 二聚体之间存在显著相关性（p = 0.046），血糖与年龄之间存在显著相关性（p = 0.017）。
慢性高血糖会增加高凝状态的风险，这也会增加合并恶性肿瘤的糖尿病患者的发病率和死亡率。
