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从马约特泻湖采集的海洋海绵中的新代谢物。

New Metabolites from the Marine Sponge Collected in Mayotte Lagoon.

机构信息

Laboratoire de Chimie et de Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS 92003, CEDEX 09, 97744 Saint-Denis, France.

CNRS, Centrale Marseille, FSCM, Spectropole, Aix Marseille Université, Campus de St Jérôme-Service 511, 13397 Marseille, France.

出版信息

Mar Drugs. 2022 Mar 2;20(3):186. doi: 10.3390/md20030186.

DOI:10.3390/md20030186
PMID:35323485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8951328/
Abstract

The biological screening of 44 marine sponge extracts for the research of bioactive molecules, with potential application in the treatment of age-related diseases (cancer and Alzheimer's disease) and skin aging, resulted in the selection of extract for chemical study. As no reports of secondary metabolites of were found in the literature, we undertook this research to further extend current knowledge of chemistry. The investigation of this species led to the discovery of four new compounds: two butenolides sinularone J () and sinularone K (), one phospholipid 1--octadecyl-2-pentanoyl--glycero-3-phosphocholine () and one lysophospholipid 1--(3-methoxy-tetradecanoyl)--glycero-3-phosphocholine () alongside with known lysophospholipids ( and ), alkylglycerols (-), epidioxysterols ( and ) and diketopiperazines ( and ). The structure elucidation of the new metabolites (-) was determined by detailed spectroscopic analysis, including 1D and 2D NMR as well as mass spectrometry. Molecular networking was also explored to complement classical investigation and unravel the chemical classes within this species. GNPS analysis provided further information on potential metabolites with additional bioactive natural compounds predicted.

摘要

为了研究具有治疗与年龄相关疾病（癌症和老年痴呆症）和皮肤老化潜力的生物活性分子，我们对 44 种海洋海绵提取物进行了生物筛选，从中选择了 提取物进行化学研究。由于在文献中未发现 的次级代谢产物的报道，我们进行了此项研究，以进一步扩展 化学的现有知识。对该物种的研究发现了四个新化合物：两个丁烯内酯 sinularone J () 和 sinularone K (), 一种磷脂 1--十八烷基-2-戊酰基--甘油-3-磷酸胆碱 () 和一种溶血磷脂 1--(3-甲氧基-十四烷酰基)--甘油-3-磷酸胆碱 ()，以及已知的溶血磷脂 ( 和 ), 烷基甘油 (-), 表二氧甾醇 ( 和 ) 和二酮哌嗪 ( 和 )。通过详细的光谱分析，包括 1D 和 2D NMR 以及质谱，确定了新代谢物 (-) 的结构。还探索了分子网络以补充经典研究并揭示该物种中的化学类别。GNPS 分析提供了有关潜在代谢物的更多信息，并预测了其他具有生物活性的天然化合物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/1a75a13f4978/marinedrugs-20-00186-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/fe21dcf9c0bc/marinedrugs-20-00186-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/36989259b6aa/marinedrugs-20-00186-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/f580a9e7a3e5/marinedrugs-20-00186-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/6c910c4b02bd/marinedrugs-20-00186-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/7d184d860fd1/marinedrugs-20-00186-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/1a75a13f4978/marinedrugs-20-00186-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/fe21dcf9c0bc/marinedrugs-20-00186-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/36989259b6aa/marinedrugs-20-00186-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/f580a9e7a3e5/marinedrugs-20-00186-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/6c910c4b02bd/marinedrugs-20-00186-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/7d184d860fd1/marinedrugs-20-00186-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b706/8951328/1a75a13f4978/marinedrugs-20-00186-g006.jpg

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