Pain and Rehabilitation Centre, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SWEDEN.
Department of Dental Medicine, Karolinska Institutet, and Scandinavian Centre for Orofacial Neurosciences (SCON), Huddinge, SWEDEN.
Med Sci Sports Exerc. 2020 Jul;52(7):1617-1628. doi: 10.1249/MSS.0000000000002293.
Physical exercise is increasingly being promoted by health care for chronic pain conditions with beneficial outcomes, such as pain and fatigue reduction, and increased quality of life. Nevertheless, knowledge about biochemical consequences of physical exercise in chronic pain is still relatively poor. The endocannabinoid system has been suggested to play a role for acute exercise-induced reward and pain inhibition. The aim of this study is to investigate the chronic outcomes of resistance exercise on levels of endocannabinoids and related lipids in fibromyalgia (FM).
This study examine the outcomes of a 15-wk person-centered resistance exercise program on plasma levels of the lipid mediators; anandamide, 2-arachidonoylglycerol (2-AG), oleoylethanolamide, palmitoylethanolamide, and stearoylethanolamide (SEA) sampled from 37 women with FM and 33 healthy controls. The associations between clinical scorings of pain, depression, anxiety, fatigue, and muscle strength with levels of these lipid mediators before and after the exercise program are also analyzed.
After the 15-wk exercise program, anandamide levels were significantly increased, and SEA levels significantly decreased in FM. Pain intensity and depression scorings decreased and muscle strength increased, and in a multivariate context, muscle strength was positively associated with 2-AG levels after the resistance exercise program in FM.
The increased anandamide and decreased SEA in women with FM after the 15-wk program might point to a chronic effect of resistance exercise. Pain and depression scorings decreased in the FM group after the program, but no associations between pain, depression, and lipid level changes were assured.
越来越多的医疗保健专业人士提倡进行身体锻炼，以治疗慢性疼痛疾病，从而带来有益的效果，如减轻疼痛和疲劳，提高生活质量。然而，关于身体锻炼对慢性疼痛的生化影响的知识仍然相对匮乏。内源性大麻素系统被认为在急性运动引起的奖励和疼痛抑制中起作用。本研究旨在探讨抗阻运动对纤维肌痛（FM）患者内源性大麻素和相关脂质水平的慢性影响。
本研究调查了 15 周以患者为中心的抗阻运动方案对 37 名 FM 女性和 33 名健康对照者血浆中脂代谢物水平的影响，这些脂代谢物包括：大麻素 1-花生四烯酸甘油（anandamide）、2-花生四烯酸甘油（2-AG）、油酰乙醇酰胺（oleoylethanolamide）、棕榈酰乙醇酰胺（palmitoylethanolamide）和硬脂酰乙醇酰胺（SEA）。还分析了这些脂质代谢物水平与运动方案前后 FM 患者的疼痛、抑郁、焦虑、疲劳和肌肉力量的临床评分之间的关系。
在 15 周的运动方案后，FM 患者的 anandamide 水平显著升高，SEA 水平显著降低。疼痛强度和抑郁评分降低，肌肉力量增加，在多变量背景下，FM 患者的肌肉力量与抗阻运动方案后的 2-AG 水平呈正相关。
在进行 15 周的抗阻运动方案后，FM 患者体内的 anandamide 增加，SEA 减少，这可能表明抗阻运动的慢性作用。方案后 FM 组的疼痛和抑郁评分降低，但疼痛、抑郁与脂质水平变化之间的关联并未得到证实。
