Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Expert Rev Respir Med. 2020 Jun;14(6):577-586. doi: 10.1080/17476348.2020.1743182. Epub 2020 Mar 17.
: Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury common in critically ill patients and characterized by significant morbidity and mortality. It frequently manifests long-lasting effects beyond hospitalization, from cognitive impairment to physical weakness.: Several complications of ARDS have been identified in patients after hospital discharge. The authors conducted literature searches to identify observational studies, randomized clinical trials, systematic reviews, and guidelines. A summary of is presented here to outline the sequelae of ARDS and their risk factors with a focus on the limited but growing research into possible therapies. Long term sequelae of ARDS commonly identified in the literature include long-term cognitive impairment, psychological morbidities, neuromuscular weakness, pulmonary dysfunction, and ongoing healthcare utilization with reduced quality of life.: Given the public health significance of long-term complications following ARDS, the development of new therapies for prevention and treatment is of vital importance. Furthering knowledge of the pathophysiology of these impairments will provide a framework to develop new therapeutic targets to fuel future clinical trials in this area of critical care medicine.
急性呼吸窘迫综合征（ARDS）是一种严重的急性肺损伤，常见于重症患者，其特点是发病率和死亡率高。它经常在住院后产生持久的影响，从认知障碍到身体虚弱。
在出院后，患者出现了几种 ARDS 并发症。作者进行了文献检索，以确定观察性研究、随机临床试验、系统评价和指南。这里概述了 ARDS 的后遗症及其危险因素，重点介绍了对可能治疗方法的有限但不断增加的研究。文献中常见的 ARDS 长期后遗症包括长期认知障碍、心理病态、神经肌肉无力、肺功能障碍以及持续的医疗保健利用，生活质量降低。
鉴于 ARDS 后长期并发症的公共卫生意义，开发预防和治疗这些并发症的新疗法至关重要。深入了解这些损伤的病理生理学将为开发新的治疗靶点提供框架，以推动该重症监护医学领域的未来临床试验。
