Pentecost B T, Newbold R R, Teng C T, McLachlan J A
Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences Research Triangle Park, North Carolina 27709.
Mol Endocrinol. 1988 Dec;2(12):1243-8. doi: 10.1210/mend-2-12-1243.
We have previously isolated an estrogen-inducible secretory protein, lactotransferrin (LTF), and a cDNA to its messenger RNA from the uterus of mice. In this report we determined that the level of LTF mRNA is minimal in the seminal vesicles of normal mice. In contrast, expression of LTF mRNA in the seminal vesicles of developmentally estrogenized males was both constitutive and estrogen inducible. The results suggested that this alteration may be an example of atypical gene expression after hormonal manipulation early in development.
我们之前从小鼠子宫中分离出一种雌激素诱导分泌蛋白——乳铁传递蛋白（LTF）及其信使核糖核酸的互补脱氧核糖核酸（cDNA）。在本报告中，我们测定了正常小鼠精囊中LTF信使核糖核酸的水平极低。相比之下，在发育过程中经雌激素处理的雄性小鼠精囊中，LTF信使核糖核酸的表达既是组成型的，又是雌激素诱导型的。结果表明，这种改变可能是发育早期激素操纵后非典型基因表达的一个例子。
