Winiarska H M, Cofta S, Bielawska L, Płóciniczak A, Piorunek T, Wysocka E
Department of Respiratory Medicine, Allergology and Pulmonary Oncology, Poznan University of Medical Sciences, Poznan, Poland.
Department of Laboratory Diagnostics, Poznan University of Medical Sciences, Poznan, Poland.
Adv Exp Med Biol. 2020;1279:61-69. doi: 10.1007/5584_2020_501.
Selectins and their ligands play an important role in atherosclerosis. The role of these adhesion molecules in the pathogenesis of obstructive sleep apnea (OSA) may be of clinical relevance. Therefore, the aim of this study was to assess the serum content of platelet P-selectin (P-SEL) and P-selectin glycoprotein ligand 1 (PSGL-1) in different OSA stages. The study was performed in nondiabetic patients, aged 32-71, in whom OSA was verified by polysomnography. The apnea/hypopnea index (AHI) was used to stratify OSA stages: AHI <5, no sleep pathology (OSA-0); AHI 5-15, (OSA-1); AHI 16-30, (OSA-2); and AHI >30, (OSA-3). There were 16 patients in each group. P-SEL and PSGL-1 were assessed by ELISA kits. There were no appreciable differences in the patients' glucose or high-specificity C-reactive protein content. We found that P-SEL and PSGL-1 significantly increased from OSA-0 to OSA-3. There were the following positive associations in all OSA patients: P-SEL vs. AHI, PSGL-1 vs. AHI, and P-SEL vs. PSGL-1. In addition, the adhesion molecules are associated with the anthropometric parameters, oxygen saturation, and sleep architecture in the OSA-1 group. We conclude that the adhesion molecules consistently increase in the blood of nondiabetic OSA patients, along with progression of disorder severity.
选择素及其配体在动脉粥样硬化中起重要作用。这些黏附分子在阻塞性睡眠呼吸暂停（OSA）发病机制中的作用可能具有临床意义。因此，本研究旨在评估不同OSA阶段血小板P选择素（P-SEL）和P选择素糖蛋白配体1（PSGL-1）的血清含量。该研究在年龄为32 - 71岁的非糖尿病患者中进行，这些患者的OSA通过多导睡眠图进行了验证。呼吸暂停/低通气指数（AHI）用于对OSA阶段进行分层：AHI <5，无睡眠病理（OSA-0）；AHI 5 - 15，（OSA-1）；AHI 16 - 30，（OSA-2）；以及AHI >30，（OSA-3）。每组有16名患者。通过ELISA试剂盒评估P-SEL和PSGL-1。患者的血糖或高特异性C反应蛋白含量没有明显差异。我们发现从OSA-0到OSA-3，P-SEL和PSGL-1显著增加。在所有OSA患者中存在以下正相关：P-SEL与AHI、PSGL-1与AHI以及P-SEL与PSGL-1。此外，在OSA-1组中，黏附分子与人体测量参数、血氧饱和度和睡眠结构相关。我们得出结论，随着病情严重程度的进展，非糖尿病OSA患者血液中的黏附分子持续增加。
