Division of Clinical Physiology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Dental Anesthesiology, Nagasaki University Hospital, Nagasaki, Japan.
Fisher & Paykel Healthcare Ltd, Auckland, New Zealand.
Respir Physiol Neurobiol. 2020 Jun;277:103429. doi: 10.1016/j.resp.2020.103429. Epub 2020 Mar 12.
Hypoventilation and carbon dioxide (CO) retention are common during sedation. The current study investigated the ventilation responses to nasal high flow (NHF) during sedation with propofol.
NHF of 30 L/min and 60 L/min with room air was applied during wakefulness and sedation in 10 male volunteers. Ventilation was monitored by respiratory inductance plethysmography, transcutaneous partial pressure of CO (TcCO), and SpO.
During sedation, NHF of 30 L/min and 60 L/min reduced the TcCO by 2.9 ± 2.7 mmHg (p = 0.025) and by 3.6 ± 3.4 mmHg (p = 0.024) without affecting SpO and reduced the mean respiratory rate by 3 ± 3 breaths/min (p = 0.011) and by 4 ± 3 breaths/min (p = 0.003), respectively.
During sedation with propofol, NHF without supplemental oxygen attenuated CO retention and reduced the respiratory rate. The findings show that NHF can improve ventilation during sedation, which may reduce the risk of complications related to hypoventilation.
镇静时常出现通气不足和二氧化碳（CO）潴留。本研究旨在探究在丙泊酚镇静时应用经鼻高流量（NHF）对通气的影响。
10 名男性志愿者在清醒和镇静时分别接受 30L/min 和 60L/min 的 NHF 联合室内空气治疗。通过呼吸感应体积描记法、经皮 CO 分压（TcCO）和 SpO 监测通气情况。
在镇静时，30L/min 和 60L/min 的 NHF 分别降低 TcCO2.9±2.7mmHg（p=0.025）和 3.6±3.4mmHg（p=0.024），而不影响 SpO，分别降低平均呼吸频率 3±3 次/分钟（p=0.011）和 4±3 次/分钟（p=0.003）。
在丙泊酚镇静时，不补充氧气的 NHF 可减轻 CO 潴留并降低呼吸频率。这些发现表明，NHF 可改善镇静时的通气，从而降低与通气不足相关并发症的风险。
